I have been to both places and surrounding areas and like to share my experience with you.
if you go to Las Vegas I suggest you don't miss Grand Canyon, which, in my view, is breath-taking.
My last trip was as following.
Fly LA (or SF, you can spend two days or three there), drive to San Diego, then Las Vegas, ( I stayed one night, you can stay two nights), drive to Grand Canyon, (I stayed one night there but I wish I had more time), then back to LA.
You can also do multi-city flight to save some driving time.
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