mRNA疫苗的ADE效应在体外实验被证实。结论是：omicron感染会在疫苗注射群体里，激发一定程度的ADE

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Reevaluation of antibody-dependent enhancement of infection in anti-SARS-CoV-2 therapeutic antibodies and mRNA-vaccine antisera using FcR- and ACE2-positive cells​

• Jun Shimizu,
• Tadahiro Sasaki,
• Ritsuko Koketsu,
• Ryo Morita,
• Yuka Yoshimura,
• Ami Murakami,
• Yua Saito,
• Toshie Kusunoki,
• Yoshihiro Samune,
• Emi E. Nakayama,
• Kazuo Miyazaki &
• Tatsuo Shioda

Scientific Reports volume 12, Article number: 15612 (2022) Cite this article

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Abstract​

Many therapeutic antibodies (Abs) and mRNA vaccines, both targeting SARS-CoV-2 spike protein (S-protein), have been developed and approved in order to combat the ongoing COVID-19 pandemic. In consideration of these developments, a common concern has been the potential for Ab-dependent enhancement (ADE) of infection caused by inoculated or induced Abs. Although the preventive and therapeutic effects of these Abs are obvious, little attention has been paid to the influence of the remaining and dwindling anti-S-protein Abs in vivo. Here, we demonstrate that certain monoclonal Abs (mAbs) approved as therapeutic neutralizing anti-S-protein mAbs for human usage have the potential to cause ADE in a narrow range of Ab concentrations. Although sera collected from mRNA-vaccinated individuals exhibited neutralizing activity, some sera gradually exhibited dominance of ADE activity in a time-dependent manner. None of the sera examined exhibited neutralizing activity against infection with the Omicron strain. Rather, some ADE of Omicron infection was observed in some sera. These results suggest the possible emergence of adverse effects caused by these Abs in addition to the therapeutic or preventive effect.

 

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None of the sera examined exhibited neutralizing activity against infection with the Omicron strain. Rather, some ADE of Omicron infection was observed in some sera.

所检查的血清均未表现出对抗Omicron菌株感染的中和活性。 相反，在一些血清中观察到一些 Omicron 感染的 ADE。

Omicron时代，不仅不防病毒，反而导致ADE?

圈儿不走极端，平衡地看，首先这是体外实验。还没有在体内证明。其次，即便有ADE，应该也不是很严重。但是如果长期反复打疫苗，然后病毒继续变异。

发生严重ADE的情况，将只是时间问题。