中国科学家在柳叶刀预印本平台上发表研究:新冠病毒最初或在这里出现

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中国科学家发表研究:新冠病毒最初或在这里出现​

文章来源: 多维 于 2020-11-28 09:38:24 - 新闻取自各大新闻媒体,新闻内容并不代表本网立场!
(被阅读 13812 次)

题为The Early Cryptic Transmission and Evolution of Sars-CoV-2 in Human Hosts(暂译:《Sars-CoV-2在人类宿主中的早期秘密传播和进化》)的论文,11月17日在英国权威医学杂志《柳叶刀》(The Lancet)预印本平台(Preprint Platform)ssrn.com发布。

是次研究由中国科学院上海生命科学研究院博士Shen Libing率领。研究人员从17国家及地区提供的病毒株,追踪到病毒最初或在印度或孟加拉出现。

研究小组称利用新冠病毒全基因组排序,找出变异最少的病毒株。他们称根据简约原则,称变异最少的病毒株应最接近新冠病毒的“原始祖先”。

他们的结论是:“武汉不是新冠病毒第一个发生人传人的地方。”

研究人员称在4大洲的8个国家中发现变异最少的病毒株,包括澳大利亚、孟加拉、希腊、美国、俄罗斯、意大利、印度及捷克。

自从疫情爆发初期起,以美国为首的一些国家指新冠病毒源自中国,包括澳大利亚在内一些国家要求调查病毒源头。然而续有一些科学论文(包括意大利及巴西等)指出,病毒有可能在2019年12月31日中国武汉通报出现病毒性肺炎之前,已在其他国家出现。

外国专家质疑

这篇论文引起一些外国专家质疑,格拉斯哥大学(Glasgow University)教授罗伯逊(David Robertson)向英国《每日邮报》发声明称,文章“非常有缺憾”,指撰写论文的人判别“变异最少”的病毒基因排序,是固有地偏误(inherently biased)。

印度政府的病毒学家塔库尔(Mukesh Thakur)以电邮回应香港媒体查询时称对中国的研究表示不同意,“看来有误释结果的情况”。他没有进一步就此阐释。

美国加州大学洛杉矶分校生物统计学和人类遗传学系教授苏祖哈德称(Marc Suchard)称从一个任意组成的病毒株集合中,检视看来与其他病毒株相比有最少不同的基因排序,是不可能得出冠状病毒的祖细胞(progenitor)。

 

lindamy

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lancet-header

Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication. Authors have opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early stage research papers that have not been peer-reviewed. The findings should not be used for clinical or public health decision making and should not be presented to a lay audience without highlighting that they are preliminary and have not been peer-reviewed. For more information on this collaboration, see the comments published in The Lancet about the trial period, and our decision to make this a permanent offering, or visit The Lancet´s FAQ page, and for any feedback please contact preprints@lancet.com.

The Early Cryptic Transmission and Evolution of SARS-CoV-2 in Human Hosts​

22 Pages Posted: 17 Nov 2020

Libing Shen

Chinese Academy of Sciences (CAS) - Institute of Neuroscience

Funan He

Fudan University - School of Life Sciences

Zhao Zhang

University of Texas at Houston - Department of Biochemistry and Molecular Biology
More...

Abstract​

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is first identified in Wuhan City at the end of December 2019 and responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. So far this pandemic has claimed more than one million lives all over the world and its origin is still unknown.

Methods: In this study, we developed a method to search the least mutated strain using SARS-CoV-2 whole genome sequences. By parsimony principle, the least mutated strain should be the phylogenetic root for all SARS-CoV-2s. We further investigated the SARS-CoV-2’s adaptive evolutionary process in human hosts using the least mutated strain as the phylogenetic root and analyzed its strain diversity in different countries/regions.

Findings: According to their coding region identity, we classified 4571 SARS-CoV-2 genome sequences into 2449 viral strains collected from human hosts between December 2019 and July 2020. We found that the SARS-CoV-2 (NC_045512) strain first identified in Wuhan is not the least mutated strain. There are 41 SARS-CoV-2 strains harboring fewer global point mutations than the NC_045512 strain in our dataset. The least mutated strain can be found in eight countries across four continents due to SARS-CoV-2’s low mutability. Eight positive selection sites are identified in five SARS-CoV-2’s genes and four of them were present in the early stage of SARS-CoV-2’s human-to-human transmission. The NC_045512 strain has two positive selection sites, one in RNA-dependent RNA polymerase (L314P) and the other in spike protein (G614D). The statistical analysis of the SARS-CoV-2’s strain diversity in different countries/regions shows that the Indian subcontinent has the highest strain diversity. Furthermore, based on the SARS-CoV-2’s mutation rate, we estimate that the earliest SARS-CoV-2 transmission in human hosts could be traced back to July or August of 2019.

Interpretation: Our result shows that Wuhan is not the place where human-to-human SARS-CoV-2 transmission first happened. Before it spread to Wuhan, SARS-CoV-2 has already experienced adaptive evolution during its human-to-human transmission. The positive selection sites could contribute to the different clinical features of different SARS-CoV-2 strains. Both the least mutated strain’s geographic information and the strain diversity suggest that the Indian subcontinent might be the place where the earliest human-to-human SARS-CoV-2 transmission occurred, which was three or four months prior to the Wuhan outbreak. Our study helps to elucidate the early cryptic transmission and evolution of SARS-CoV-2 in human hosts and provide the new thinking for the global management of the COVID-19 pandemic.

Funding Statement: None to declare.

Declaration of Interests: None to declare.

Keywords: SARS-CoV-2, Covid-19, cryptic transmission, adaptive evolution, human host
Suggested Citation:

Shen, Libing and He, Funan and Zhang, Zhao, The Early Cryptic Transmission and Evolution of SARS-CoV-2 in Human Hosts. Available at SSRN:
The Early Cryptic Transmission and Evolution of SARS-CoV-2 in Human Hosts by Libing Shen, Funan He, Zhao Zhang :: SSRN or http://dx.doi.org/10.2139/ssrn.3724275

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file:///C:/Users/Hong%20zhu/Documents/China/The%20early%20cryptic%20transmission%20and%20evolution%20of%20SARS%20CoV%202%20in%20human%20hosts.pdf
 

livingeverywhere

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只要不是在武汉最初出现,其他哪里都行,这是政治任务。
 

ztbll

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土工军方实验室改造的病毒,为击败美帝的超限战手段之一,土工自己的书里若干年前,写的明明白白的。
 

yanngoyan

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中国科学家的研究结果必须符合土共的预定结论,否则自身和家人没有好下场,这样的研究结果能揭露真相吗?
 

渥村一民

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中国科学家的研究结果必须符合土共的预定结论,否则自身和家人没有好下场,这样的研究结果能揭露真相吗?
你说得对。试想一下,如果这个研究结果是最早在武汉出现,这个结果还能发表吗?
 

ztbll

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土工一直致力于生物基因武器,这也是堂而皇之的大国战略。


1606618142748.png
 

chicago666

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xjb扯蛋的人哪能想到有一天,他也有说到点子上的时候。
 

ztbll

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现在回看老新闻,真是别有滋味啊,此情此景,细思及恐啊。

1606619147728.png
 

livingeverywhere

你删贴,就说明你特别害怕我说的,相信JB和贺锦丽真赢8100万选票的人,基本上有认知障碍,离他们远点
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早就有预案了
 

YCT

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这次总算搞对了甩锅的方向,就是印度!!!之前甩给美帝和欧洲,被人狂打脸,智商让人捉急呀。
 

向问天

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当年西班牙把流感甩给美国就很成功。
 

newM

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注意是预印本。有关新冠的研究鱼龙混杂,泥沙俱下。科学已经被政治裹挟,利用。
 
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