疫苗时代,聊HCQ

贵圈

灭活灭活重组
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Editorial Commentary
Systematic review of registered trials of Hydroxychloroquine prophylaxis for COVID-19 health-care workers at the first third of 2020​

Author links open overlay panelAnne-LiseBienvenuabAileen M.MartycMalcolm K.JonesdStephanePicotbe
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Abstract​

In the absence of a vaccine the medical and scientific community is looking intensely at utilizing a pre or post exposure drug that could decrease viremia. The search for a medication that could reduce risk of serious disease, and ideally of any manifestation of disease from SARS-CoV2, and of asymptomatic shedding of SARS-CoV2 is of urgent interest. Repurposing existing pharmaceuticals is among the approaches to achieve these ends. We performed a systematic review of all interventional studies registered in ClinicalTrials.gov with a focus on one repurposed drug, Hydroxychloroquine (HCQ). The detailed analysis of these studies, some of them already recruiting, provide an overall picture of HCQ use as a COVID-19 prophylaxis around the world. Among the included studies, all but three were randomized and parallel and most of them (74%, 23/31) were double-blinded to quadruple-blinded studies. We found a great diversity in dosing and nearly all the possible scientifically reasonable regimens are under evaluation. This diversity offers benefits as well as challenges. Importantly, the final analysis of these trials should be done through an extensive reading of the results in regard to the clinical design, it will be crucial to carefully read and evaluate the results of each study in regards to the clinical design rather than quickly glancing a 140 characters-based social media message announcing the failure or success of a drug against a disease.
 

longshan

上知天文 下晓地理 学富五车 横贯东西
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Editorial Commentary
Systematic review of registered trials of Hydroxychloroquine prophylaxis for COVID-19 health-care workers at the first third of 2020​

Author links open overlay panelAnne-LiseBienvenuabAileen M.MartycMalcolm K.JonesdStephanePicotbe
Show more
Add to Mendeley
Share
Cite
RedirectingGet rights and content
Under a Creative Commons license
open access

Abstract​

In the absence of a vaccine the medical and scientific community is looking intensely at utilizing a pre or post exposure drug that could decrease viremia. The search for a medication that could reduce risk of serious disease, and ideally of any manifestation of disease from SARS-CoV2, and of asymptomatic shedding of SARS-CoV2 is of urgent interest. Repurposing existing pharmaceuticals is among the approaches to achieve these ends. We performed a systematic review of all interventional studies registered in ClinicalTrials.gov with a focus on one repurposed drug, Hydroxychloroquine (HCQ). The detailed analysis of these studies, some of them already recruiting, provide an overall picture of HCQ use as a COVID-19 prophylaxis around the world. Among the included studies, all but three were randomized and parallel and most of them (74%, 23/31) were double-blinded to quadruple-blinded studies. We found a great diversity in dosing and nearly all the possible scientifically reasonable regimens are under evaluation. This diversity offers benefits as well as challenges. Importantly, the final analysis of these trials should be done through an extensive reading of the results in regard to the clinical design, it will be crucial to carefully read and evaluate the results of each study in regards to the clinical design rather than quickly glancing a 140 characters-based social media message announcing the failure or success of a drug against a disease.
你是不是吃这个氯喹吃上瘾了 虽然 嗑药 兴奋剂有很多种 氯喹也可以
 

longshan

上知天文 下晓地理 学富五车 横贯东西
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你最好去医院看看 你指定有点毛病 基本上你的表现就跟 邻居二大妈 差不多
基本上就是如果重复1000遍别人就会相信你说的 这个在精神病上的是有专门定义的
 

多伦多carpool

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一个治疗疟疾的药,便宜到一毛钱加币一粒的药,这里有大把,假如有用,政府会不用吗?
世界性瘟疫靠这个药就能治,你自己信吗?
 

ztbll

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一个治疗疟疾的药,便宜到一毛钱加币一粒的药,这里有大把,假如有用,政府会不用吗?
世界性瘟疫靠这个药就能治,你自己信吗?
就是因为太便宜了,没有利益集团推,这是浅显的道理。如果告诉你他的功用接近疫苗的6,7成,甚至更高一点,疫苗还有价值吗?
 
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