CNN 文件显示,冠状病毒的基因序列在中国正式披露前两周已提交给美国数据库

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Genetic sequence of coronavirus was submitted to US database two weeks before China’s official disclosure, documents show​

By Katherine Dillinger, CNN
4 minute read

Updated 9:27 PM EST, Wed January 17, 2024

This illustration, created at the Centers for Disease Control and Prevention (CDC), reveals ultrastructural morphology exhibited by coronaviruses. Note the spikes that adorn the outer surface of the virus, which impart the look of a corona surrounding the virion, when viewed electron microscopically. A novel coronavirus, named Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), was identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China in 2019. The illness caused by this virus has been named coronavirus disease 2019 (COVID-19).

The genetic sequence itself doesn't indicate the origins of the virus that causes Covid-19
Alissa Eckert/Dan Higgins/CDC

CNN — The genetic sequence of SARS-CoV-2, the virus that causes Covid-19, was submitted to a National Institutes of Health database two weeks before its release by the Chinese government, according to documents that were shared with US lawmakers and released Wednesday.

The sequence doesn’t indicate the origin of the coronavirus but undermines the Chinese government’s claims about its knowledge of the information, one expert told CNN – and could have cost critical weeks in the development of a vaccine against the virus.

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On December 28, 2019, virologist Dr. Lili Ren of the Institute of Pathogen Biology at the Chinese Academy of Medical Sciences & Peking Union Medical College submitted the genetic sequence to GenBank, a “genetic sequence repository that collects, preserves, and provides public access to assembled and annotated nucleotide sequence data from all domains of life,” according to a letter that Dr. Melanie Egorin, assistant secretary of legislation at the US Department of Health and Human Services, sent to House Energy and Commerce Committee Chair Cathy McMorris Rodgers last month.

GenBank is managed by the National Center for Biotechnology Information, part of the US National Institutes of Health.

Ren’s submission “was incomplete and lacked the necessary information required for publication,” the letter says. She was sent a resubmission request three days later, but “NIH never received the additional information requested.” The submission was removed from a processing queue on January 16, 2020, and “the sequence was never made publicly available on GenBank.”

However, a different submission of the genetic sequence that was “nearly identical” to Ren’s was published on GenBank on January 12, Egorin said, one day after the World Health Organization said it had received the sequence from China.
McMorris Rodgers, R- Washington; Subcommittee on Health Chair Brett Guthrie, R-Kentucky; and Subcommittee on Oversight and Investigations Chair Morgan Griffith, R-Virginia, said in a news release Wednesday that the committee’s investigation into the origins of Covid-19 will help policymakers strengthen the nation’s biosafety practices in addition to helping prepare for the next pandemic.

Members of staff of the Wuhan Hygiene Emergency Response Team drive their vehicle as they leave the closed Huanan Seafood Wholesale Market in the city of Wuhan, in Hubei, Province on January 11, 2020, where the Wuhan health commission said that the man who died from a respiratory illness had purchased goods. - China said on January 11, 2020 that a 61-year-old man had become the first person to die from a respiratory illness believed to be caused by a new virus from the same family as SARS (Sudden Acute Respiratory Syndrome), which claimed hundreds of lives more than a decade ago. Forty-one people with pneumonia-like symptoms have so far been diagnosed with the new virus in Wuhan, with one of the victims dying on January 8, 2020, the central Chinese city's health commission said on its website. (Photo by NOEL CELIS / AFP) (Photo by NOEL CELIS/AFP via Getty Images)

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Scientists parse another clue to possible origins of Covid-19 as WHO says all possibilities ‘remain on the table’

They noted that they received the new information almost two months after they informed the NIH of their intent to issue subpoenas for copies of documents related to any early coronavirus sequences, early Covid-19 cases or other pertinent information.

Dr. Jesse Bloom, a virologist at the Fred Hutchinson Cancer Center, wrote Wednesday in an analysis of Ren’s submission that it “clearly falsifies the Chinese government’s claim that the causative agent of the Wuhan pneumonia outbreak still had not been identified near the end of the first week of January 2020.”

The earlier submission “would have provided adequate information to initiate vaccine production in late 2019 if it had been made public,” he said, noting that drugmaker Moderna “used the spike sequence to design its COVID-19 vaccine” within two days of the January 12 release.

However, he said, the genetic sequence “is unlikely to represent the first virus that infected humans” and “does not provide any new insights into the origin or early spread of SARS-CoV-2 in Wuhan.”

“The belated discovery of the submission underscores the importance of rapid data sharing during outbreaks, since immediate public release of the sequence could have accelerated by several weeks the development of COVID-19 vaccines that saved thousands of lives per week in the United States alone,” he said.

Even two weeks “would have made a huge difference in the pandemic,” agreed Dr. Eric Topol, founder and director of the Scripps Research Translational Institute. The fact that the vaccine program began immediately on publication of the genetic sequence “shows you how important that sequence was.”

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“When you sequence a virus – it’s not even just a vaccine – then you’ve nailed it. You know exactly the features, about the spike protein and all the other major components: the nucleocapsid, the envelope, the whole entire panoramic view of the virus. You can’t get that without the sequence.”

The documents should be read in the context of hindsight, says Dr. Kristian Andersen, an evolutionary biologist and director of infectious disease genomics at the Translational Institute.

“In late 2019, nobody knew that a pandemic would later ensue,” he wrote in an email. “This is a really critical part that most people seem to forget – nobody knew back then that a never-before-seen coronavirus only distantly related to SARS-CoV-1 was causing ‘mysterious’ illnesses in patients associated with a wet market in the middle of Wuhan, which would later spark a devastating pandemic.

“Should the sequence have been released at the time and [marked] as preliminary data? Sure, that would have been great, and is a good example of where we could hope to do better in the future,” he said. “Whoever reviewed the sequence at NCBI over the holiday period in 2019 would have no way of connecting this sequence to a ‘mysterious’ illness in Wuhan – because it was yet to be reported.”

CNN’s Jen Christensen and Brenda Goodman contributed to this report.

 

中国实验室绘制出新冠图谱两周后,北京才向世界公布​

美国国会调查人员称,中国研究人员于2019年12月底分离出导致新冠肺炎的病毒并绘制了基因图谱,这比中国政府向全世界披露该病毒的细节早了至少两周,由此再次引发对中国在疫情初期掌握哪些信息的质疑。​


1705592923667.png


2020年,中国前总理李克强在位于北京的中国医学科学院病原生物学研究所。

图片来源:CHINA NEWS SERVICE/REUTERS

Warren P. Strobel
2024年1月18日09:30 CST 更新

美国国会调查人员称,中国研究人员于2019年12月底分离出了导致新冠肺炎的病毒并绘制了其图谱,这比中国政府向全世界披露这种夺走很多生命的病毒的细节早了至少两周,由此再次引发对于中国在新冠疫情至关重要的初期掌握哪些信息的质疑。

众议院一个委员会从美国卫生与公众服务部(U.S. Department of Health and Human Services)获取的文件显示,2019年12月28日,北京有一名中国研究人员向一个由美国政府管理的数据库上传了近乎完整的该病毒基因序列。《华尔街日报》(The Wall Street Journal)见到了这些文件。当时,中国官员在公开场合仍将暴发于中国武汉的这种疾病描述为“原因不明”的病毒性肺炎,且尚未关闭华南海鲜批发市场。该市场是新冠疫情的最初暴发地点之一。

据美国政府的疫情时间表,中国到2020年1月11日才与世界卫生组织(World...

 
鉴定一种新型冠状病毒导致人类严重肺炎:一项描述性研究

2020年02月10日

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秦川|金奇|曹彬|王健伟

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新型冠状病毒肺炎

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1788

第一作者:任丽丽 1, 王业明 2,3, 吴志强 4, 相子春 1, 郭丽 1, 许腾 5, 江永忠 6, 熊燕 7

通讯作者:秦川 8, 金奇 4, 曹彬 2,3, 王健伟 1

1 中国医学科学院北京协和医学院病原生物学研究所,中国医学科学院病原生物学研究所,国立卫生研究院病原体系统生物学国家重点实验室和克里斯托弗·梅里埃实验室,北京 100730;

2 中日友好医院国家呼吸疾病临床研究中心呼吸内科,急诊医学科,北京 100029;

3 北京协和医学院中国医学科学院呼吸医学研究所,北京 100029

4 中国医学科学院北京协和医学院病原生物学研究所,国立卫生研究院病原微生物系统生物学国家重点实验室,北京 100730;

5 视觉医疗有限公司,广东广州 510000;

6 湖北省疾病预防控制中心,湖北武汉 430079;

7 武汉市疾病预防控制中心,湖北武汉 430022;

8 中国医学科学院北京协和医学院实验动物科学研究所,北京 100021;

摘要

背景:人类感染人畜共患型冠状病毒(CoV),包括严重的急性呼吸综合症(SARS)-CoV 和中东呼吸综合症(MERS)-CoV,引起了全球公众的极大关注。 在这里,我们报告了一种新的蝙蝠起源的冠状病毒,会导致人类严重和致命的肺炎。

方法:我们从湖北省武汉市金银潭医院收集了 5 例重症肺炎患者的临床资料和支气管肺泡灌洗(BAL)标本。 提取 BAL 的核酸并进行下一代测序。进行了病毒分离,并构建了最大似然系统树。

结果:2019 年 12 月 18 日至 12 月 29 日住院的 5 例患者出现发烧,咳嗽和呼吸困难,并伴有急性呼吸窘迫综合征的并发症。胸部 X 线摄片显示弥漫性浸润性病灶。其中一名患者死亡。序列结果显示所有五名患者中均存在先前未知的β-CoV 毒株,分离株之间的核苷酸同源性为 99.8%–99.9%。这些分离物显示出与 SARS-CoV 序列(GenBank NC_004718)具有 79.0% 的核苷酸同源性,并且与 MERS-CoV 序列(GenBank NC_019843)具有 51.8% 的同源性。该病毒在系统发育上最接近蝙蝠 SARS 样冠状病毒(SL-ZC45,GenBank MG772933),具有 87.6%–87.7% 的核苷酸同源性,但处于单独的进化支中。而且,这些病毒具有单个完整的开放阅读框基因编码 8,作为蝙蝠起源的 CoVs 进一步指标。但是,暂定受体结合结构域的氨基酸序列与 SARS-CoV 相似,表明这些病毒可能使用相同的受体。

结论:鉴定出一种新型蝙蝠传播的冠状病毒,与人类严重和致命的呼吸道疾病有关。

关键字:蝙蝠起源;冠状病毒;人畜共患病的传播;肺炎; 病因学; 下一代测序

点击查看原文

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冲锋在疫情科技支撑第一线的巾帼斗士

——记中国医学科学院病原生物学研究所任丽丽研究员

启明星下清冷的北风寒气逼人。正月初七的凌晨,中国医学科学院病原生物学研究所会议室里依旧灯火通明,任丽丽研究员正在向各位专家和领导汇报新型冠状病毒实验室检测工作志愿者的培训方案,至此会议已持续了5个多小时。
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这是什么信号呢?
 
怪不得呢。
 
宁汉合流啊:zhichi:
五花

不是猪

我家有只大狗,五花的,
会看人脸色,但是并不会看事儿。你竟是狗,智商不够。

CFC很多人,看人不看事儿。遗憾。上来啥也不看,就知道文革那一套。
 
如果美国提前知道基因序列,至少四种情况,实际可能的情况必然更多。

1. 中国早就知道基因序列,隐而不发,生物圈研究人员是一体,互相通气。因而外传。比如fool7这类专家,也许早就手握信息了,药厂更是神通广大。不在话下。
2. 中国早就知道基因序列,隐而不发,美国在中国的商业和政治间谍搞到了
3. 中国没有提前确切知道,但美国早就知道,因为病毒研制是在美国,或者使用了美国提供的技术或基因信息。
4. 中国政府没有提前确切知道,但科研人员早就拿到手了,因为想发文章,而迟迟没有上交。反而被同行审议知道了。
 
最后编辑:
任丽丽博士在2019年12月28日向基因数据库提交了不明肺炎病毒的基因测序,不完整,被要求提供补充数据,没有后续,在2020年1月16日这个数据被移除,从来未对外界公开发表。

我的理解,这个移除是因为数据不完整,应当是基因库,而不是中国做的。
 
正如稀土所说:

在咱们这个世界里,信息是不对称。
普罗草民得到消息,常常是过时,失效,甚至是虚假的。
圈儿来自平行世界。在他的那个世界里,每个人都是股神。
既来之则安之,凑合着过吧 :tx:
 
哈哈哈,翻旧账了,土工官方提供最少2次基因序列,故意用错误的。当时不少实验室自己测出的,最准的是上海一个实验室,随后就被关闭了。
 
信息不对成,还信。这就是范伟在人海里找本山买拐。一定要有自己的判断,即便信息不完整,不完全真实。很多时候,都可以用朴素的逻辑思维迅速看穿。

躺平,信,

这显然不是解决之道。

有这倾向的,就是范伟。
 
4年啦,还是猪一样啊。
 
疫情爆发一段时间以后的事情,其实无关紧要。这是避重就轻,不痛不痒。
很多中美机构参与了这个病毒的开发。武汉所提供原料,北卡完成病毒改造。
那个环节发生泄漏不得而知。曝光出来,大家都吃不了兜着走。
 
如果美国提前知道基因序列,至少四种情况,实际可能的情况必然更多。

1. 中国早就知道基因序列,隐而不发,生物圈研究人员是一体,互相通气。因而外传。比如fool7这类专家,也许早就手握信息了,药厂更是神通广大。不在话下。
2. 中国早就知道基因序列,隐而不发,美国在中国的商业和政治间谍搞到了
3. 中国没有提前确切知道,但美国早就知道,因为病毒研制是在美国,或者使用了美国提供的技术或基因信息。
4. 中国政府没有提前确切知道,但科研人员早就拿到手了,因为想发文章,而迟迟没有上交。反而被同行审议知道了。
你说的1. 2.不对,这个可能是中国两个星期以前就主动给美国了。起码CNN文章中的意思是这个。
至于公开宣布,那是两个星期以后了,中美都知道。
宁汉合流啊:zhichi:
没毛病
 
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