自然免疫看来是要重新审视了.

[贵圈]

Continued Effectiveness of COVID-19 Vaccination among Urban Healthcare Workers during Delta Variant Predominance​

View ORCID ProfileFan-Yun Lan, Amalia Sidossis, Eirini Iliaki, Jane Buley, Neetha Nathan, Lou Ann Bruno-Murtha, Stefanos N. Kales
doi: Continued Effectiveness of COVID-19 Vaccination among Urban Healthcare Workers during Delta Variant Predominance
This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.

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Abstract​

Background Data on COVID-19 vaccine effectiveness (VE) among healthcare workers (HCWs) during periods of delta variant predominance are limited.
Methods We followed a population of urban Massachusetts HCWs (45% non-White) subject to epidemiologic surveillance. We accounted for covariates such as demographics and community background infection incidence, as well as information bias regarding COVID-19 diagnosis and vaccination status.
Results and Discussion During the study period (December 16, 2020 to September 30, 2021), 4615 HCWs contributed to a total of 1,152,486 person-days at risk (excluding 309 HCWs with prior infection) and had a COVID-19 incidence rate of 5.2/10,000 (114 infections out of 219,842 person-days) for unvaccinated person-days and 0.6/10,000 (49 infections out of 830,084 person-days) for fully vaccinated person-days, resulting in an adjusted VE of 82.3% (95% CI: 75.1–87.4%). For the secondary analysis limited to the period of delta variant predominance in Massachusetts (i.e., July 1 to September 30, 2021), we observed an adjusted VE of 76.5% (95% CI: 40.9–90.6%). Independently, we found no re-infection among those with prior COVID-19, contributing to 74,557 re-infection-free person-days, adding to the evidence base for the robustness of naturally acquired immunity.

 

[贵圈]

摘要​

在 delta 變異優勢期間，醫護人員 (HCW) 中 COVID-19 疫苗有效性 (VE) 的背景數據是有限的。
方法我們追踪了接受流行病學監測的馬薩諸塞州城市醫護人員（45% 為非白人）。我們考慮了諸如人口統計學和社區背景感染髮生率等協變量，以及關於 COVID-19 診斷和疫苗接種狀態的信息偏差。
結果和討論在研究期間（2020 年 12 月 16 日至 2021 年 9 月 30 日），4,615 名 HCW 貢獻了總共 1,152,486 人日的風險（不包括 309 名既往感染的 HCW），並且 COVID-19 的發病率為 5.2/10,000 219,842 人日中的 114 次感染）對於未接種疫苗的人日和 0.6/10,000（830,084 人日中的 49 次感染）對於完全接種疫苗的人日，導致調整後的 VE 為 82.3%（95% CI：75.1–） 87.4%）。對於僅限於馬薩諸塞州 delta 變異優勢時期（即 2021 年 7 月 1 日至 9 月 30 日）的二級分析，我們觀察到調整後的 VE 為 76.5%（95% CI：40.9-90.6%）。獨立地，我們發現先前患有 COVID-19 的人沒有再次感染，導致 74,557 個無再次感染人日，為自然獲得性免疫的穩健性增加了證據基礎。

 

[billwanhua]

看来靠抗体浓度解决不了问题，mRNA抗体浓度高感染康复者体内浓度的几倍。除了可测的抗体浓度，应该还有很多人类没有认知的东西在起作用。

一味强调抗体浓度，不停打加强针提高抗体应该要重新思考

 

[RareEarth]

早说了不能小看自然免疫。呵呵。 光靠疫苗不解决问题。只有自然免疫代价太大。 必须把两个合在一起考虑。
疫苗覆盖率达到一定程度，立刻全面开放，在疫苗的辅助作用下建立自然群体免疫。这是最合理可行的方案。

 

[billwanhua]

还有一个因素，自然免疫过程中，很多老弱病残被自然淘汰了。留下来的都是精英

 

[贵圈]

大过滤器！