Omicron
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引起癌症高发，佛罗里达总卫生官呼吁停止mRNA新冠疫苗注射，因为污染接受者DNA，严重有害
- 主题发起人 Omicron
- 开始时间
廊坊头条
.
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- 2021-06-25
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是的，washingtonpost.com 之外，nytimes.com 也报道了，这可不是哪个自媒体，都是相当 formal 的大报纸，还是州总卫生管在呼吁。
www.nytimes.com
Citing Misinformation, Florida Health Official Calls for Halt to Covid Vaccines (Published 2024)
Federal health officials and other experts have repeatedly sought to counter erroneous comments about the vaccines by Dr. Joseph Ladapo, Florida’s surgeon general.
Omicron
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原文
content.govdelivery.com
Florida State Surgeon General Calls for Halt in the Use of COVID-19 mRNA Vaccines
- DNA integration could theoretically impact a human’s oncogenes – the genes which can transform a healthy cell into a cancerous cell.
- DNA integration may result in chromosomal instability.
- The Guidance for Industry discusses biodistribution of DNA vaccines and how such integration could affect unintended parts of the body including blood, heart, brain, liver, kidney, bone marrow, ovaries/testes, lung, draining lymph nodes, spleen, the site of administration and subcutis at injection site.
贵圈
政府都对党
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Abstract
In vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). IVT mRNAs are transfected into target cells, where they are translated into recombinant protein, and the biological activity or immunogenicity of the encoded protein exerts an intended therapeutic effect1,2. Modified ribonucleotides are commonly incorporated into therapeutic IVT mRNAs to decrease their innate immunogenicity3,4,5, but their effects on mRNA translation fidelity have not been fully explored. Here we demonstrate that incorporation of N1-methylpseudouridine into mRNA results in +1 ribosomal frameshifting in vitro and that cellular immunity in mice and humans to +1 frameshifted products from BNT162b2 vaccine mRNA translation occurs after vaccination. The +1 ribosome frameshifting observed is probably a consequence of N1-methylpseudouridine-induced ribosome stalling during IVT mRNA translation, with frameshifting occurring at ribosome slippery sequences. However, we demonstrate that synonymous targeting of such slippery sequences provides an effective strategy to reduce the production of frameshifted products. Overall, these data increase our understanding of how modified ribonucleotides affect the fidelity of mRNA translation, and although there are no adverse outcomes reported from mistranslation of mRNA-based SARS-CoV-2 vaccines in humans, these data highlight potential off-target effects for future mRNA-based therapeutics and demonstrate the requirement for sequence optimization.
N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting - Nature
A study demonstrates that nucleotide modifications in mRNA-based therapeutics can lead to +1 ribosomal frameshifting during translation, yielding products that can trigger immune responses.