美国已发现5800人接种疫苗后感染新冠病毒

[billwanhua]

谁说的？

一直都这样

这个视频说的，还有这个也说了：

How Effective Is the Johnson & Johnson COVID-19 Vaccine? Here’s What You Should Know

We asked UCSF infectious disease expert Monica Gandhi, MD, MPH, to unpack some of the big questions around vaccine science, such as how the Johnson & Johnson vaccine differs, how well it works against the new variants, and whether you should be worried about transmitting the virus after vaccination.

www.ucsf.edu

 

[koppie644]

90%嘛，这个数目是非常不错的了

 

[lindamy]

CDC报道的这个完全免疫后感染的比率 22/15000 = 0.15% 比那个5800/77millions = 0.0075%高近20倍，和2月以色列报道的608/602000 = 0.1%的比例接近

8 min ago

Breakthrough Covid-19 infections "rare" among fully vaccinated nursing home residents, CDC says​

From CNN’s Jen Christensen

Most fully vaccinated residents of nursing homes were not infected, even after someone in the same facility tested positive for Covid-19, according to a new study that looked at infections in nursing homes in Chicago from the US Centers for Disease Control and Prevention.

Among the nearly 8,000 residents and nearly 7,000 staff that have received two doses of a Covid-19 vaccine since December, there were only 22 breakthrough infections among the fully vaccinated, according to the CDC’s Weekly Morbidity and Mortality Report published on Wednesday.

The CDC considers people to be fully vaccinated two weeks after the second dose of the Pfizer or Moderna vaccine or two weeks after the single Johnson & Johnson vaccine.

Of the 22 breakthrough cases, there were 12 residents and 10 staff members who tested positive for Covid-19 after being fully vaccinated. Two-thirds of those who tested positive, 14 people, were asymptomatic. Two residents were hospitalized and one of those residents died, the CDC said. The person who died had three underlying conditions, according to the CDC.

There was no facility-associated secondary transmission.

Although they are rare, the CDC said breakthrough infections can happen because no Covid-19 vaccine provides 100% protection. While some earlier studies suggested that the vaccines provide total protection against severe illness and death, data on vaccination and transmission in congregate settings like nursing homes has been limited.

Some context: The CDC said that this study confirms how important it is for people to get vaccinated, particularly in congregate settings where it is difficult to keep physical distance.

The study also shows that nursing homes still need to follow recommended infection and control practices. Residents who get Covid-19 still need to be isolated from others and residents that have had close contact with them should be quarantined. Nursing homes should continue regular testing and staff should continue to wear PPE, regardless of vaccination status.

“Maintaining high vaccination coverage among residents and staff members is also important to reduce opportunities for transmission within facilities and exposure among persons who might not have achieved protective immunity after vaccination,” the report concluded.

 

[春夏秋鼕]

Scientist who helped develop Pfizer-BioNTech Covid vaccine agrees third shot is needed as immunity wanes

The chief medical officer of BioNTech told CNBC that people will likely need a third shot of its two-dose Covid-19 vaccine as immunity against the virus wanes.

www.cnbc.com

• The chief medical officer of BioNTech told CNBC that people will likely need a third shot of its two-dose Covid-19 vaccine as immunity against the virus wanes.
• Dr. Ozlem Tureci, the co-founder and CMO of BioNTech, which developed a Covid vaccine with Pfizer, said she also expects people will need to get vaccinated against the coronavirus annually, like for the seasonal flu.

 

[billwanhua]

CDC报道的这个完全免疫后感染的比率 22/15000 = 0.15% 比那个5800/77millions = 0.0075%高近20倍，和2月以色列报道的608/602000 = 0.1%的比例接近

8 min ago

Breakthrough Covid-19 infections "rare" among fully vaccinated nursing home residents, CDC says​

From CNN’s Jen Christensen

Most fully vaccinated residents of nursing homes were not infected, even after someone in the same facility tested positive for Covid-19, according to a new study that looked at infections in nursing homes in Chicago from the US Centers for Disease Control and Prevention.

Among the nearly 8,000 residents and nearly 7,000 staff that have received two doses of a Covid-19 vaccine since December, there were only 22 breakthrough infections among the fully vaccinated, according to the CDC’s Weekly Morbidity and Mortality Report published on Wednesday.

The CDC considers people to be fully vaccinated two weeks after the second dose of the Pfizer or Moderna vaccine or two weeks after the single Johnson & Johnson vaccine.

Of the 22 breakthrough cases, there were 12 residents and 10 staff members who tested positive for Covid-19 after being fully vaccinated. Two-thirds of those who tested positive, 14 people, were asymptomatic. Two residents were hospitalized and one of those residents died, the CDC said. The person who died had three underlying conditions, according to the CDC.

There was no facility-associated secondary transmission.

Although they are rare, the CDC said breakthrough infections can happen because no Covid-19 vaccine provides 100% protection. While some earlier studies suggested that the vaccines provide total protection against severe illness and death, data on vaccination and transmission in congregate settings like nursing homes has been limited.

Some context: The CDC said that this study confirms how important it is for people to get vaccinated, particularly in congregate settings where it is difficult to keep physical distance.

The study also shows that nursing homes still need to follow recommended infection and control practices. Residents who get Covid-19 still need to be isolated from others and residents that have had close contact with them should be quarantined. Nursing homes should continue regular testing and staff should continue to wear PPE, regardless of vaccination status.

几个因素：
1.老人容易感染，打了疫苗免疫能力也不足
2.养老院经常测试，所以更容易测出感染病人，而社会上除非重病，很多都不检测
3.这些数字要对比同时期没有打疫苗的人感染几率才有意义

 

[uf65ca]

An unvaccinated worker set off an outbreak at a U.S. nursing home where most residents were immunized.

New infections of inoculated residents are occurring, signaling the need to maintain safety measures, C.D.C. studies show.

www.nytimes.com

The study estimated that the vaccine, identified as Pfizer-BioNTech, showed effectiveness of 66 percent for residents and 75.9 percent for employees, and were 86 percent to 87 percent effective at protecting against symptomatic disease.

看来对对付变种 也就那样。
实战效果貌似不比智利强到哪

 

[billwanhua]

An unvaccinated worker set off an outbreak at a U.S. nursing home where most residents were immunized.

New infections of inoculated residents are occurring, signaling the need to maintain safety measures, C.D.C. studies show.

www.nytimes.com

The study estimated that the vaccine, identified as Pfizer-BioNTech, showed effectiveness of 66 percent for residents and 75.9 percent for employees, and were 86 percent to 87 percent effective at protecting against symptomatic disease.

看来对对付变种 也就那样。
实战效果貌似不比智利强到哪

不一定变种，大规模爆发，病人多，接触病毒浓度高，次数频繁，可能实际有效性没有那么高，
加拿大也发生过同样的事：

https://www.cbc.ca/news/canada/british-columbia/new-outbreak-covid-bc-care-home-1.5941508

She said some of the cases were among people who had received two doses of the vaccine.

 

[lindamy]

几个因素：
1.老人容易感染，打了疫苗免疫能力也不足
2.养老院经常测试，所以更容易测出感染病人，而社会上除非重病，很多都不检测
3.这些数字要对比同时期没有打疫苗的人感染几率才有意义

以色列2月报道的那个608/602000 = 0.1%的完全免疫后感染还都是因为35%有症状，65%有与感染者有密切接触的人测试确诊的。如果完全无症状普查，感染率会更高。

 

[lindamy]

这个“突破”完全免疫的比例是2/417 = 0.47%,文中的.005%多了两个0，或者是百分号。

40 min ago

Only 2 "breakthrough" infections among hundreds of fully vaccinated people, new study finds​

From CNN's Jacqueline Howard

For fully vaccinated people, the risk of still getting Covid-19 – described as "breakthrough infections" – remains extremely low, a new study out of New York suggests.

Among 417 employees at Rockefeller University who were fully vaccinated with either the Pfizer or Moderna shots, two of them or about .005%, had breakthrough infections later, according to the study published on Wednesday in the New England Journal of Medicine.

"We have characterized bona fide examples of vaccine breakthrough manifesting as clinical symptoms," the researchers wrote in their study. "These observations in no way undermine the importance of the urgent efforts being taken at the federal and state levels to vaccinate the U.S. population. They also lend support to efforts to advance a new vaccine booster (as well as a pan-coronavirus vaccine) to provide increased protection against variants."
The researchers, from Rockefeller University, found that coronavirus variants with several differences from the original virus caused the breakthrough infections.

A variant that infected one of the patients had the mutation E484K, which was first found in the B.1.351 variant originally identified in South Africa. E484K has been called an "escape mutant" because it has shown it might be able to escape some of the antibodies produced by coronavirus vaccines. One of the mutations found in both study participants' infections included D614G, which emerged early in the pandemic.

One of the breakthrough infections was in a healthy 51-year-old woman who received her second dose of the Moderna vaccine on February 19. Nineteen days later, she tested positive for Covid-19 on March 10 after developing symptoms.

The other breakthrough infection was in a healthy 65-year-old woman who received her second dose of the Pfizer vaccine on February 9. She later learned that her partner, who was unvaccinated, tested positive for Covid-19 on March 3. In the following days, the woman developed symptoms of her own. She tested positive for Covid-19 on March 17.

More research is needed to determine whether similar findings related to breakthrough infections or variants would emerge among a larger group of participants from various parts of the United States.

For context: The US Centers for Disease Control and Prevention told CNN last week that the agency has so far received less than 6,000 reports of breakthrough coronavirus infections among more than 84 million people fully vaccinated nationwide.