抗体半衰期:是covid病毒特别还是新技术mRNA不能持久?

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部分传染病抗体半衰期:水痘-带状疱疹病毒的抗体半衰期长达92年,针对风疹病毒的抗体半衰期长达114年,针对腮腺炎病毒的抗体半衰期可达542年,麻疹抗体半衰期长达3014年。而相比之下,针对破伤风或白喉的特异性抗体半衰期就要快得多,分别为11年和19年。虽然抗体的半衰期长短和保护时间长短有关有一定关联,但还要考虑抗体水平、自然感染情况、个体差异等因素,因此不能单独从半衰期来定义自然感染或接种疫苗后保护时期的长短。
 
好奇问一句, 流感疫苗半衰期?
 
以色列的研究显示,自然免疫比疫苗的保护率高13倍以上。

Israeli study shows natural immunity delivers 13 times more protection than COVID vaccines​

Posted by John Ley
Date: Wednesday, November 10, 2021

Smaller CDC study shows vaccines offer better protection​

As the Delta wave of COVID-19 continues to decline from its mid-September peak in Washington state, many people are concerned about the declining efficacy of the three approved vaccines from the Food and Drug Administration. The government has authorized “at risk” patients to begin getting a booster shot of any of the Pfizer, Moderna, or Johnson and Johnson vaccines.

Yet an estimated 745,000 Washington citizens have already recovered from COVID-19 according to the Washington Department of Health (DOH). Their body has successfully fought the virus and has developed not only antibodies, but B and T cell lymphocytes to provide a defense should the individual encounter the virus again.

Last week, the DOH launched a new “vaccine verification” tool. The system provides a digital copy of state vaccine records according to the website. “You may also show your CDC provided COVID-19 card or your state immunization record,” the website states if you are required to show “proof” of vaccination status. There is no mention of natural immunity.

Does the body’s natural defense system, or the “natural immunity” one acquires after having COVID-19, offer better protection than the three FDA approved vaccines? Should someone with natural immunity be required to get a vaccination anyway?

The Centers for Disease Control and Prevention (CDC) has weighed in, issuing a report Friday evening. Reviewing scores of research studies and its own unpublished data, the agency found that both infection-induced and vaccine-induced immunity are durable for at least six months — but that vaccines are more consistent in their protection and offer a huge boost in antibodies for people previously infected, according to one news report.

The body develops a natural immune response to COVID-19 after having been sick from the virus. There are not only antibodies, but also B and T cell lymphocytes that offer protection from a future infection.


The body develops a natural immune response to COVID-19 after having been sick from the virus. There are not only antibodies, but also B and T cell lymphocytes that offer protection from a future infection.

However a recent Israeli study shows that natural immunity is 13 times more effective than vaccines in protecting individuals. “SARS-CoV-2-naïve vaccines had a 13-fold increased risk for breakthrough infection with the Delta variant compared to those previously infected.”

Yet the smaller CDC study offers a different conclusion, that the vaccines offer better protection. While the Israeli study had 10 times more people, they primarily used the Pfizer-BioNTech vaccine. In the U.S., three are approved, including the Pfizer, the Moderna, and Johnson & Johnson vaccines.

“The increased risk was significant for symptomatic disease as well,” states the Israeli report. There was waning natural immunity identified as well. However, vaccinated individuals had “a 5.96-fold increased risk for breakthrough infection and a 7.13-fold increased risk for symptomatic disease.” There was also a greater risk for COVID-19-related hospitalizations compared to those that were previously infected.

Israel is one of the most vaccinated countries in the world. This summer they experienced a “fourth wave” of the Delta variant of COVID-19 including those who were allegedly “protected” by the vaccine. Israel has over 1.3 million people who got sick from the virus and 8,130 who died.

“This study demonstrated that natural immunity confers longer lasting and stronger protection against infection, symptomatic disease and hospitalization caused by the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity,” said the Israeli study. “Individuals who were both previously infected with SARS-CoV-2 and given a single dose of the vaccine gained additional protection against the Delta variant.”

The Israeli study period was March 1, 2020 to August 14, 2021. They used a database of Maccabi Healthcare Services (MHS), Israel’s second largest Health Maintenance Organization.

It is a 2.5-million-member, state-mandated, non-for-profit, second largest health fund in Israel, which covers 26 percent of the population and provides a representative sample of the Israeli population..
During the summer “fourth wave” of COVID-19 cases, Israel battled the Delta variant which caused significant numbers of “breakthrough” cases of people who had been vaccinated. Graphic courtesy Jennifer Margulis


During the summer “fourth wave” of COVID-19 cases, Israel battled the Delta variant which caused significant numbers of “breakthrough” cases of people who had been vaccinated. Graphic courtesy Jennifer Margulis

Overall, 673,676 MHS members 16 years and older were eligible for the study group of fully vaccinated SARS-CoV-2-naïve individuals; 62,883 were eligible for the study group of unvaccinated previously infected individuals and 42,099 individuals were eligible for the study group of previously infected and single-dose vaccines.

Conversely, the CDC touts a study which came to a different conclusion.

Researchers from CDC’s VISION network gathered data from 187 hospitals across nine states. These were New York, Minnesota, Wisconsin, Utah, California, Oregon, Washington, Indiana, and Colorado, according to one report.

An analysis of the data showed that 7,348 people, or a little over 3 percent of the participants, met the study criteria. Among the 6,328 people who were fully vaccinated, 324 (or 5.1 percent) had a positive COVID-19 PCR test. Among the 1,020 who were unvaccinated and who had previously had the infection, 89 (or 8.7 percent) had a positive COVID-19 PCR test.

According to the study authors, “These findings suggest that among hospitalized adults with COVID-19-like illness whose previous infection or vaccination occurred 90–179 days earlier, vaccine-induced immunity was more protective than infection-induced immunity against laboratory-confirmed COVID-19.”
Dr. William Schaffner, a professor of medicine in the Division of Infectious Diseases at Vanderbilt University School of Medicine in Nashville, TN, commented on the CDC study.

He said: “For a long time, we’ve known that people [who have the infection], if they are subsequently vaccinated, will have much higher levels of antibodies than people who [have the infection] but are not vaccinated. Natural infection plus vaccination is better than natural infection alone.”

Some say the different results may be related to differences in the methods of the two studies and restrictions on the timing of vaccinations. It should be noted that the Israeli study had a pool of people 10 times larger than the number in the CDC study. They also primarily used the Pfizer mRNA vaccine.

Dr. Marty Makary, a professor at Johns Hopkins University School of Medicine and editor in chief of MedPage Today, argues that mandating vaccines for “every living, walking American” is, as of now, not well-supported by science.

Dr. Marty Makary is a professor of surgery at Johns Hopkins and is also the editor of Medpagetoday.com. He indicates the evidence shows strong support for natural immunity. He cites over 15 different studies showing natural immunity provides better protection than the vaccines, and therefore should be acknowledged by public health officials. Graphic courtesy Medpagetoday.com


Dr. Marty Makary is a professor of surgery at Johns Hopkins and is also the editor of Medpagetoday.com. He indicates the evidence shows strong support for natural immunity. He cites over 15 different studies showing natural immunity provides better protection than the vaccines, and therefore should be acknowledged by public health officials. Graphic courtesy Medpagetoday.com

“Some people already have ‘natural immunity’ – that is, immunity from prior COVID infection,” he said in August. “During every month of this pandemic, I’ve had debates with other public researchers about the effectiveness and durability of natural immunity. I’ve been told that natural immunity could fall off a cliff, rendering people susceptible to infection.

“But here we are now, over a year and a half into the clinical experience of observing patients who were infected, and natural immunity is effective and going strong. And that’s because with natural immunity, the body develops antibodies to the entire surface of the virus, not just a spike protein constructed from a vaccine.

“The power of natural immunity was recently affirmed in an Israeli study, which found a 6.7 times greater level of protection among those with natural immunity vs. those with vaccinated immunity,” he said.

In September, Makary shared that there are more than 15 studies that have demonstrated the power of immunity acquired by previously having the virus. He referenced Israel “found that those who had experienced prior infections were 27 times less likely to get a second symptomatic covid infection than those who were vaccinated.”

This affirmed a June Cleveland Clinic study of health-care workers (who are often exposed to the virus), in which none who had previously tested positive for the coronavirus got reinfected. The study authors concluded that “individuals who have had SARS-CoV-2 infection are unlikely to benefit from covid-19 vaccination.” In May, a Washington University study found that even a mild COVID infection resulted in long-lasting immunity.

Makary shared a commonly asked question. “I’ve recovered from covid, is it absolutely essential that I get vaccinated?” Many public health officials have put aside the data and responded with a synchronized “yes,” even as studies have shown that reinfections are rare and often asymptomatic or mild when they do occur, he said.

Presently, the CDC and Washington state officials do not recognize “natural immunity” when it comes to the vaccine mandates issued by the Biden Administration or the Jay Inslee administration.

 
可能6个月,呵呵

您说得对 :good: :good: :good:

Q34. 為何每年都要接種流感疫苗?

由於流感病毒極易產生變異,幾乎每年流行的病毒株都會稍有不同,原施打疫苗對不同抗原型之病毒保護效果減低,即使病毒未發生變異,疫苗成分相同,接種4-6個月後保護效果即可能下降,保護力一般不超過1年,因此建議每年均須接種1次,是全球一致性的作法。
 
从效果看,重组蛋白新冠疫苗非常好,现在就看持续时间有多长。古巴是世界上唯一全部使用重组蛋白新冠疫苗(疫苗为古巴自行研制)的国家,完整接种率71%,疫苗覆盖率90%,如今已将日新增确诊病例压至300例,新增死亡病例为0。古巴曾经疫情很高,8,9月每天近1万
 
最后编辑:
以色列的研究显示,自然免疫比疫苗的保护率高13倍以上。

Israeli study shows natural immunity delivers 13 times more protection than COVID vaccines​

Posted by John Ley
Date: Wednesday, November 10, 2021

Smaller CDC study shows vaccines offer better protection​

As the Delta wave of COVID-19 continues to decline from its mid-September peak in Washington state, many people are concerned about the declining efficacy of the three approved vaccines from the Food and Drug Administration. The government has authorized “at risk” patients to begin getting a booster shot of any of the Pfizer, Moderna, or Johnson and Johnson vaccines.

Yet an estimated 745,000 Washington citizens have already recovered from COVID-19 according to the Washington Department of Health (DOH). Their body has successfully fought the virus and has developed not only antibodies, but B and T cell lymphocytes to provide a defense should the individual encounter the virus again.

Last week, the DOH launched a new “vaccine verification” tool. The system provides a digital copy of state vaccine records according to the website. “You may also show your CDC provided COVID-19 card or your state immunization record,” the website states if you are required to show “proof” of vaccination status. There is no mention of natural immunity.

Does the body’s natural defense system, or the “natural immunity” one acquires after having COVID-19, offer better protection than the three FDA approved vaccines? Should someone with natural immunity be required to get a vaccination anyway?

The Centers for Disease Control and Prevention (CDC) has weighed in, issuing a report Friday evening. Reviewing scores of research studies and its own unpublished data, the agency found that both infection-induced and vaccine-induced immunity are durable for at least six months — but that vaccines are more consistent in their protection and offer a huge boost in antibodies for people previously infected, according to one news report.

The body develops a natural immune response to COVID-19 after having been sick from the virus. There are not only antibodies, but also B and T cell lymphocytes that offer protection from a future infection.


The body develops a natural immune response to COVID-19 after having been sick from the virus. There are not only antibodies, but also B and T cell lymphocytes that offer protection from a future infection.

However a recent Israeli study shows that natural immunity is 13 times more effective than vaccines in protecting individuals. “SARS-CoV-2-naïve vaccines had a 13-fold increased risk for breakthrough infection with the Delta variant compared to those previously infected.”

Yet the smaller CDC study offers a different conclusion, that the vaccines offer better protection. While the Israeli study had 10 times more people, they primarily used the Pfizer-BioNTech vaccine. In the U.S., three are approved, including the Pfizer, the Moderna, and Johnson & Johnson vaccines.

“The increased risk was significant for symptomatic disease as well,” states the Israeli report. There was waning natural immunity identified as well. However, vaccinated individuals had “a 5.96-fold increased risk for breakthrough infection and a 7.13-fold increased risk for symptomatic disease.” There was also a greater risk for COVID-19-related hospitalizations compared to those that were previously infected.

Israel is one of the most vaccinated countries in the world. This summer they experienced a “fourth wave” of the Delta variant of COVID-19 including those who were allegedly “protected” by the vaccine. Israel has over 1.3 million people who got sick from the virus and 8,130 who died.

“This study demonstrated that natural immunity confers longer lasting and stronger protection against infection, symptomatic disease and hospitalization caused by the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity,” said the Israeli study. “Individuals who were both previously infected with SARS-CoV-2 and given a single dose of the vaccine gained additional protection against the Delta variant.”

The Israeli study period was March 1, 2020 to August 14, 2021. They used a database of Maccabi Healthcare Services (MHS), Israel’s second largest Health Maintenance Organization.

It is a 2.5-million-member, state-mandated, non-for-profit, second largest health fund in Israel, which covers 26 percent of the population and provides a representative sample of the Israeli population..
During the summer “fourth wave” of COVID-19 cases, Israel battled the Delta variant which caused significant numbers of “breakthrough” cases of people who had been vaccinated. Graphic courtesy Jennifer Margulis


During the summer “fourth wave” of COVID-19 cases, Israel battled the Delta variant which caused significant numbers of “breakthrough” cases of people who had been vaccinated. Graphic courtesy Jennifer Margulis

Overall, 673,676 MHS members 16 years and older were eligible for the study group of fully vaccinated SARS-CoV-2-naïve individuals; 62,883 were eligible for the study group of unvaccinated previously infected individuals and 42,099 individuals were eligible for the study group of previously infected and single-dose vaccines.

Conversely, the CDC touts a study which came to a different conclusion.

Researchers from CDC’s VISION network gathered data from 187 hospitals across nine states. These were New York, Minnesota, Wisconsin, Utah, California, Oregon, Washington, Indiana, and Colorado, according to one report.

An analysis of the data showed that 7,348 people, or a little over 3 percent of the participants, met the study criteria. Among the 6,328 people who were fully vaccinated, 324 (or 5.1 percent) had a positive COVID-19 PCR test. Among the 1,020 who were unvaccinated and who had previously had the infection, 89 (or 8.7 percent) had a positive COVID-19 PCR test.

According to the study authors, “These findings suggest that among hospitalized adults with COVID-19-like illness whose previous infection or vaccination occurred 90–179 days earlier, vaccine-induced immunity was more protective than infection-induced immunity against laboratory-confirmed COVID-19.”
Dr. William Schaffner, a professor of medicine in the Division of Infectious Diseases at Vanderbilt University School of Medicine in Nashville, TN, commented on the CDC study.

He said: “For a long time, we’ve known that people [who have the infection], if they are subsequently vaccinated, will have much higher levels of antibodies than people who [have the infection] but are not vaccinated. Natural infection plus vaccination is better than natural infection alone.”

Some say the different results may be related to differences in the methods of the two studies and restrictions on the timing of vaccinations. It should be noted that the Israeli study had a pool of people 10 times larger than the number in the CDC study. They also primarily used the Pfizer mRNA vaccine.

Dr. Marty Makary, a professor at Johns Hopkins University School of Medicine and editor in chief of MedPage Today, argues that mandating vaccines for “every living, walking American” is, as of now, not well-supported by science.

Dr. Marty Makary is a professor of surgery at Johns Hopkins and is also the editor of Medpagetoday.com. He indicates the evidence shows strong support for natural immunity. He cites over 15 different studies showing natural immunity provides better protection than the vaccines, and therefore should be acknowledged by public health officials. Graphic courtesy Medpagetoday.com


Dr. Marty Makary is a professor of surgery at Johns Hopkins and is also the editor of Medpagetoday.com. He indicates the evidence shows strong support for natural immunity. He cites over 15 different studies showing natural immunity provides better protection than the vaccines, and therefore should be acknowledged by public health officials. Graphic courtesy Medpagetoday.com

“Some people already have ‘natural immunity’ – that is, immunity from prior COVID infection,” he said in August. “During every month of this pandemic, I’ve had debates with other public researchers about the effectiveness and durability of natural immunity. I’ve been told that natural immunity could fall off a cliff, rendering people susceptible to infection.

“But here we are now, over a year and a half into the clinical experience of observing patients who were infected, and natural immunity is effective and going strong. And that’s because with natural immunity, the body develops antibodies to the entire surface of the virus, not just a spike protein constructed from a vaccine.

“The power of natural immunity was recently affirmed in an Israeli study, which found a 6.7 times greater level of protection among those with natural immunity vs. those with vaccinated immunity,” he said.

In September, Makary shared that there are more than 15 studies that have demonstrated the power of immunity acquired by previously having the virus. He referenced Israel “found that those who had experienced prior infections were 27 times less likely to get a second symptomatic covid infection than those who were vaccinated.”

This affirmed a June Cleveland Clinic study of health-care workers (who are often exposed to the virus), in which none who had previously tested positive for the coronavirus got reinfected. The study authors concluded that “individuals who have had SARS-CoV-2 infection are unlikely to benefit from covid-19 vaccination.” In May, a Washington University study found that even a mild COVID infection resulted in long-lasting immunity.

Makary shared a commonly asked question. “I’ve recovered from covid, is it absolutely essential that I get vaccinated?” Many public health officials have put aside the data and responded with a synchronized “yes,” even as studies have shown that reinfections are rare and often asymptomatic or mild when they do occur, he said.

Presently, the CDC and Washington state officials do not recognize “natural immunity” when it comes to the vaccine mandates issued by the Biden Administration or the Jay Inslee administration.



自然免疫效果最好。但是自然免疫效就要不怕死人,不怕牺牲老人,怎么感觉说的是废话。
 
以色列的研究显示,自然免疫比疫苗的保护率高13倍以上。

Israeli study shows natural immunity delivers 13 times more protection than COVID vaccines​

Posted by John Ley
Date: Wednesday, November 10, 2021

Smaller CDC study shows vaccines offer better protection​

As the Delta wave of COVID-19 continues to decline from its mid-September peak in Washington state, many people are concerned about the declining efficacy of the three approved vaccines from the Food and Drug Administration. The government has authorized “at risk” patients to begin getting a booster shot of any of the Pfizer, Moderna, or Johnson and Johnson vaccines.

Yet an estimated 745,000 Washington citizens have already recovered from COVID-19 according to the Washington Department of Health (DOH). Their body has successfully fought the virus and has developed not only antibodies, but B and T cell lymphocytes to provide a defense should the individual encounter the virus again.

Last week, the DOH launched a new “vaccine verification” tool. The system provides a digital copy of state vaccine records according to the website. “You may also show your CDC provided COVID-19 card or your state immunization record,” the website states if you are required to show “proof” of vaccination status. There is no mention of natural immunity.

Does the body’s natural defense system, or the “natural immunity” one acquires after having COVID-19, offer better protection than the three FDA approved vaccines? Should someone with natural immunity be required to get a vaccination anyway?

The Centers for Disease Control and Prevention (CDC) has weighed in, issuing a report Friday evening. Reviewing scores of research studies and its own unpublished data, the agency found that both infection-induced and vaccine-induced immunity are durable for at least six months — but that vaccines are more consistent in their protection and offer a huge boost in antibodies for people previously infected, according to one news report.

The body develops a natural immune response to COVID-19 after having been sick from the virus. There are not only antibodies, but also B and T cell lymphocytes that offer protection from a future infection.


The body develops a natural immune response to COVID-19 after having been sick from the virus. There are not only antibodies, but also B and T cell lymphocytes that offer protection from a future infection.

However a recent Israeli study shows that natural immunity is 13 times more effective than vaccines in protecting individuals. “SARS-CoV-2-naïve vaccines had a 13-fold increased risk for breakthrough infection with the Delta variant compared to those previously infected.”

Yet the smaller CDC study offers a different conclusion, that the vaccines offer better protection. While the Israeli study had 10 times more people, they primarily used the Pfizer-BioNTech vaccine. In the U.S., three are approved, including the Pfizer, the Moderna, and Johnson & Johnson vaccines.

“The increased risk was significant for symptomatic disease as well,” states the Israeli report. There was waning natural immunity identified as well. However, vaccinated individuals had “a 5.96-fold increased risk for breakthrough infection and a 7.13-fold increased risk for symptomatic disease.” There was also a greater risk for COVID-19-related hospitalizations compared to those that were previously infected.

Israel is one of the most vaccinated countries in the world. This summer they experienced a “fourth wave” of the Delta variant of COVID-19 including those who were allegedly “protected” by the vaccine. Israel has over 1.3 million people who got sick from the virus and 8,130 who died.

“This study demonstrated that natural immunity confers longer lasting and stronger protection against infection, symptomatic disease and hospitalization caused by the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity,” said the Israeli study. “Individuals who were both previously infected with SARS-CoV-2 and given a single dose of the vaccine gained additional protection against the Delta variant.”

The Israeli study period was March 1, 2020 to August 14, 2021. They used a database of Maccabi Healthcare Services (MHS), Israel’s second largest Health Maintenance Organization.

It is a 2.5-million-member, state-mandated, non-for-profit, second largest health fund in Israel, which covers 26 percent of the population and provides a representative sample of the Israeli population..
During the summer “fourth wave” of COVID-19 cases, Israel battled the Delta variant which caused significant numbers of “breakthrough” cases of people who had been vaccinated. Graphic courtesy Jennifer Margulis


During the summer “fourth wave” of COVID-19 cases, Israel battled the Delta variant which caused significant numbers of “breakthrough” cases of people who had been vaccinated. Graphic courtesy Jennifer Margulis

Overall, 673,676 MHS members 16 years and older were eligible for the study group of fully vaccinated SARS-CoV-2-naïve individuals; 62,883 were eligible for the study group of unvaccinated previously infected individuals and 42,099 individuals were eligible for the study group of previously infected and single-dose vaccines.

Conversely, the CDC touts a study which came to a different conclusion.

Researchers from CDC’s VISION network gathered data from 187 hospitals across nine states. These were New York, Minnesota, Wisconsin, Utah, California, Oregon, Washington, Indiana, and Colorado, according to one report.

An analysis of the data showed that 7,348 people, or a little over 3 percent of the participants, met the study criteria. Among the 6,328 people who were fully vaccinated, 324 (or 5.1 percent) had a positive COVID-19 PCR test. Among the 1,020 who were unvaccinated and who had previously had the infection, 89 (or 8.7 percent) had a positive COVID-19 PCR test.

According to the study authors, “These findings suggest that among hospitalized adults with COVID-19-like illness whose previous infection or vaccination occurred 90–179 days earlier, vaccine-induced immunity was more protective than infection-induced immunity against laboratory-confirmed COVID-19.”
Dr. William Schaffner, a professor of medicine in the Division of Infectious Diseases at Vanderbilt University School of Medicine in Nashville, TN, commented on the CDC study.

He said: “For a long time, we’ve known that people [who have the infection], if they are subsequently vaccinated, will have much higher levels of antibodies than people who [have the infection] but are not vaccinated. Natural infection plus vaccination is better than natural infection alone.”

Some say the different results may be related to differences in the methods of the two studies and restrictions on the timing of vaccinations. It should be noted that the Israeli study had a pool of people 10 times larger than the number in the CDC study. They also primarily used the Pfizer mRNA vaccine.

Dr. Marty Makary, a professor at Johns Hopkins University School of Medicine and editor in chief of MedPage Today, argues that mandating vaccines for “every living, walking American” is, as of now, not well-supported by science.

Dr. Marty Makary is a professor of surgery at Johns Hopkins and is also the editor of Medpagetoday.com. He indicates the evidence shows strong support for natural immunity. He cites over 15 different studies showing natural immunity provides better protection than the vaccines, and therefore should be acknowledged by public health officials. Graphic courtesy Medpagetoday.com


Dr. Marty Makary is a professor of surgery at Johns Hopkins and is also the editor of Medpagetoday.com. He indicates the evidence shows strong support for natural immunity. He cites over 15 different studies showing natural immunity provides better protection than the vaccines, and therefore should be acknowledged by public health officials. Graphic courtesy Medpagetoday.com

“Some people already have ‘natural immunity’ – that is, immunity from prior COVID infection,” he said in August. “During every month of this pandemic, I’ve had debates with other public researchers about the effectiveness and durability of natural immunity. I’ve been told that natural immunity could fall off a cliff, rendering people susceptible to infection.

“But here we are now, over a year and a half into the clinical experience of observing patients who were infected, and natural immunity is effective and going strong. And that’s because with natural immunity, the body develops antibodies to the entire surface of the virus, not just a spike protein constructed from a vaccine.

“The power of natural immunity was recently affirmed in an Israeli study, which found a 6.7 times greater level of protection among those with natural immunity vs. those with vaccinated immunity,” he said.

In September, Makary shared that there are more than 15 studies that have demonstrated the power of immunity acquired by previously having the virus. He referenced Israel “found that those who had experienced prior infections were 27 times less likely to get a second symptomatic covid infection than those who were vaccinated.”

This affirmed a June Cleveland Clinic study of health-care workers (who are often exposed to the virus), in which none who had previously tested positive for the coronavirus got reinfected. The study authors concluded that “individuals who have had SARS-CoV-2 infection are unlikely to benefit from covid-19 vaccination.” In May, a Washington University study found that even a mild COVID infection resulted in long-lasting immunity.

Makary shared a commonly asked question. “I’ve recovered from covid, is it absolutely essential that I get vaccinated?” Many public health officials have put aside the data and responded with a synchronized “yes,” even as studies have shown that reinfections are rare and often asymptomatic or mild when they do occur, he said.

Presently, the CDC and Washington state officials do not recognize “natural immunity” when it comes to the vaccine mandates issued by the Biden Administration or the Jay Inslee administration.

这个文章是在讨论新冠患者愈后所产生的自然免疫, 与通过两针接种所产生的免疫相比, 哪个保护力更强。目前还有争论, 样本不够大。

但这个文章没有讨论保护力随时间下降的问题, 没有考虑时长
 
自然免疫效果最好。但是自然免疫效就要不怕死人,不怕牺牲老人,怎么感觉说的是废话。
大概是说目前的疫苗半衰期很短,效率也比不过自然感染,但是只要能使很多老弱病残顶住重症和死亡,就算达到最高目的,其他就不要指望了。
 
部分传染病抗体半衰期:水痘-带状疱疹病毒的抗体半衰期长达92年,针对风疹病毒的抗体半衰期长达114年,针对腮腺炎病毒的抗体半衰期可达542年,麻疹抗体半衰期长达3014年。而相比之下,针对破伤风或白喉的特异性抗体半衰期就要快得多,分别为11年和19年。虽然抗体的半衰期长短和保护时间长短有关有一定关联,但还要考虑抗体水平、自然感染情况、个体差异等因素,因此不能单独从半衰期来定义自然感染或接种疫苗后保护时期的长短。
现在测出各种新冠疫苗的半衰期各为多少,3千年就不用了,10年就很好了,似乎现在是不到3个月就快衰完一大半了。
 
部分传染病抗体半衰期:水痘-带状疱疹病毒的抗体半衰期长达92年,针对风疹病毒的抗体半衰期长达114年,针对腮腺炎病毒的抗体半衰期可达542年,麻疹抗体半衰期长达3014年。而相比之下,针对破伤风或白喉的特异性抗体半衰期就要快得多,分别为11年和19年。

从这些常见传染病的例子, 是不是可以这样理解:
1、疫苗保护力无法超过得病痊愈产生的自然免疫
2、如果某种传染病, 如麻疹, 其自然免疫能长期保持, 那疫苗的免疫效果才有可能长期保持
3、如果某种传染病, 如流感, 其自然免疫就无法长期保持, 所以疫苗的免疫效果也无法持久, 需要年年打
4、新冠的情况可能是更象流感的, 听说印度、英国、美国的医护人员有些都得过两次新冠了, 可见自然免疫就无法持久。那么疫苗的保护力也就无法持久
 
大概会和流感 influenza 的疫苗一样,每年打一次,每次会对疫苗作出改进。针对好几种流行变异毒株的多联多价疫苗一定会出现。

对于未感染新冠的人群,第二针比第一针不良反应更明显,这好理解 (原理上类似曾经感染的人第一针的不良反应更明显);平均意义上第三、第四针或许和第二针情况差不多。在完成接种两剂同一种疫苗的前提下,mRNA 疫苗、重组蛋白亚单位疫苗、灭活疫苗每种类别里的优秀产品 的混合接力或许有一定道理 (腺病毒载体重组疫苗整个类别或许都不适合新冠,而每个类别里的垫底产品应该被改进或淘汰)。

检测中和抗体再决定是否打加强针对于全体人群来说不现实,对于某些 (原本打疫苗就有较大风险的) 基础疾病人群 是可行的,除此以外对于一般人群或许适合作为自费项目。在相当简易而精确的表面抗体滴度的检测方式出现前 (简易但不精确的没法采用,比如那种显示模式只有两条杠的 IgG/IgM test kit),实验室检测仍然是较精确测量抗体滴度的办法,既不简易也不便宜,操作上比施打规模化生产、标准化的疫苗更繁琐。

疫苗对于预防重症和减少死亡发挥了重要作用。病毒的进化的总体趋势可能会有利于出现某一种优势的毒株成为一段时期内的主流 (或更利于传播,或更利于突破已有一定免疫力的人群,或使得 viral load 增高,或延长无症状感染的时间),但并不是每一种优势都会导致更高死亡率。

这位网友三个月之前(8月15日)的发言, 看来还是挺靠谱的
 
我很庆幸没住在阿尔伯塔,那种做法是一场有关人命的一场豪赌。

福特政府不是宣布明年3月28日以后彻底取消所有公共卫生限制, 包括室内口罩令。那是不是等于今年夏天阿尔伯塔省的做法?

安省这个彻底开放的计划是否是基于, 明年1月到3月之间:
1、所有孩子完成两针接种
3、所有成年人完成第三针
因为全体民众都有了疫苗的保护, 开放之后实际效果是促进了感染传播, 以轻症的代价实现自然免疫?


 
流感病毒变异太快,新冠同样
新冠病毒比流感病毒变异速度还快很多倍,所以早就有专家说新冠疫苗没有什么用。
 
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