ZT 自然杂志：先灭活再R苗的“杂打”效果好

[lindamy]

自然杂志：先灭活再R苗的“杂打”效果好​

来源: fuz 于 2022-05-15 04:31:27

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant​

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant - Nature Communications

Abstract​

The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and the urgent need to study more efficient vaccination strategies.

Here we observed that an mRNA vaccine booster in individuals vaccinated with two doses of inactivated vaccine significantly increased the plasma level of specific antibodies that bind to the receptor-binding domain (RBD) or the spike (S) ectodomain (S1 + S2) of both the G614 and the Omicron variants, compared to two doses of homologous inactivated vaccine.

The level of RBD- and S-specific IgG antibodies and virus neutralization titers against variants of concern in the heterologous vaccination group were similar to that in individuals receiving three doses of homologous mRNA-vaccine or a boost of mRNA vaccine after infection, but markedly higher than that in individuals receiving three doses of a homologous inactivated vaccine.

This heterologous vaccination regime furthermore significantly enhanced the RBD-specific memory B cell response and S1-specific T cell response, compared to two or three doses of homologous inactivated vaccine.

Our study demonstrates that mRNA vaccine booster in individuals vaccinated with inactivated vaccines can be highly beneficial, as it markedly increases the humoral and cellular immune responses against the virus, including the Omicron variant.

自然杂志：先灭活再R苗的“杂打”效果好 - fuz发表于 健康养生 - 论坛 | 文学城

bbs.wenxuecity.com

 

[Jay Wang]

@贵圈

 

[廊坊头条]

中国现在也是摸着石头过河，谨慎地探索中，但愿能找出一个不全面爆发不大量死人不大量死老弱病残的人而走出疫情的路子。
即使习近平对疫情再无能，想必他身边不会缺这方面的高人。

 

[ottawa_tj]

中国可能因此大量进口mRNA。。。

 

[lindamy]

中国可能因此大量进口mRNA。。。

加拿大倒手吧

 

[SFU]

为中国进口mRNA做预热

 

[茶马盐铁]

加拿大倒手吧

想得美。 加拿大自己跳进去的坑， 中国跟你一天二地恨，三江四海仇， 凭啥帮你解套啊？ 你就在坑底带着呗。

 

[SFU]

中国现在也是摸着石头过河，谨慎地探索中，但愿能找出一个不全面爆发不大量死人不大量死老弱病残的人而走出疫情的路子。
即使习近平对疫情再无能，想必他身边不会缺这方面的高人。

希望这样

 

[lindamy]

为中国进口mRNA做预热

Nature 为中国预热？

 

[贵圈]

太好了，终于咱们每人11针，有去去处了，节省了大量的民脂民膏。救助了大量灭活的群众。

 

[贵圈]

一举三得，三德子

1救中国
2救自由党，救加拿大银的钱包
3帮助加拿大主流群众戒毒

 

[Teddy]

p-p-p 还是 p-p-m?

 

[SFU]

Nature 为中国预热？

不是nature为中国预热，而是中国政府寻找题材为mrna做准备

 

[lindamy]

不是nature为中国预热，而是中国政府寻找题材为mrna做准备

那不知道，从文学城转的文章，不在中国。

 

[aottawa]

那不知道，从文学城转的文章，不在中国。

是一个中国（籍？裔？）教授带着一帮中国，和瑞典学者在瑞典搞的研究