听圈哥的没错，成人一定要打疫苗，不要打AZ，不要混搭，不要支持强制。

[贵圈]

1. 两个mRNA不要混搭，有条件的不要打什么AZ，圈儿哥都是第一时间善意提醒过大家的。

当初，我是谨慎研究过，决定不混搭。现在混搭的可怜了。

2. 一起反对疫苗强制措施吧。现在混搭的加拿大人失去了很多在国外的工作和自由。

当你是少数的时候，他们会毫不留情的欺负你。这个先例已经开了。而且在西方世界的绝望现状下，民粹的左派会迅速的推进对医疗少数群体的无充足理由的压迫。将自己的无能，转嫁给少数群体。对他们肆意剥夺。

3. 成人，没完成疫苗接种的现在赶紧。高潮要来了。

 

[贵圈]

Mixed dose woes: Some Canadians lost out on jobs abroad due to their mixed vaccines​

Having a mixed COVID-19 vaccine — two shots but with different vaccines — may do more than impede your travel plans. It could hurt your chances of working abroad.
Several countries don't recognize people with mixed doses as being fully vaccinated.
That's the general position in the United States where the Centers for Disease Control (CDC) currently doesn't condone mixing COVID-19 vaccines.
Canadians can fly to the U.S. without showing proof of vaccination. However, many cruise lines departing the country have vaccination requirements — which are based on CDC guidelines.
As a result, some Canadian cruise ship workers say they lost out on jobs because they weren't considered fully vaccinated due to their mixed vaccines.
"It was really heartbreaking," said dancer Rosie Harbans of Toronto who performs in cruise ship shows. "This is how I make my money. This is how I live my life. This is my livelihood."
Last year, Harbans' cruise ship contract was cut short after the pandemic forced the cruise industry to shut down in March 2020.
So she was thrilled to land a job starting next month with a cruise line. But she said her joy — and her job offer — disappeared after the cruise company learned she had mixed COVID-19 doses: one Pfizer and one Moderna.
"I was very, very upset, because I thought that getting a mixed vaccine was the right thing to do," said Harbans.


Cruise ship dancer, Rosie Harbans of Toronto said she was heartbroken to discover she couldn't accept a job on a cruise ship because she has a mixed COVID-19 vaccine. (Yasmin Parodi)
To protect their future employment, CBC News has agreed to not name the cruise line involved in Harbans' case or in the case of a second cruise ship entertainer interviewed for this story.
Both said they don't blame the cruise lines, and that they are speaking out to encourage the Canadian government to push for the acceptance of mixed vaccines internationally.
"Find a solution," said Harbans. "Try and do it as quickly as possible for all of the people that took [the government's] advice in getting a mixed vaccine."
Since mid-July, the federal government has repeatedly said it's working with other countries to resolve their differing vaccine policies. But Ottawa has yet to announce any progress on that front.

No international consensus on mixed vaccines​

Millions of Canadians have received mixed COVID-19 vaccines. That's because in June, Canada updated its guidelines to recommend mixing COVID-19 vaccine doses based on emerging research that found it was both safe and effective.
But there's currently no international consensus on mixing COVID-19 vaccines.
For example, according to their government websites, both Ireland and the United Kingdom don't recognize any combination of mixed COVID-19 vaccines.
Germany and Trinidad and Tobago only recognize a mix of AstraZeneca and Pfizer or Moderna. The World Health Organization (WHO) takes the same position — with a cautionary note.
"There is currently limited data on the immunogenicity or efficacy of a 'mix and match' [COVID-19 vaccine] regimen," the WHO said in a statement.

 

[贵圈]

因为混搭就可以失去工作。

这就是政府强制措施的真实面目。

现在疫苗的防感染能力已经千疮百孔。还折腾强制。防疫意义不大。官僚权力扩增倒是真的。

世界真的被疫情彻底改变了。无可奈何话谐趣。

 

[贵圈]

不要轻信政府的，考虑事情要自己思考。

混搭可以有效，但是安全未知，而且得不到药厂的支持，得不到美国的认可。公司更是没时间听你申诉。直接开除就完了。

而加拿大政府是没有热情和实力，替你出头的。

疫情两年了，如果这一点还学不会，那就真是没办法了。

 

[wei_cheng]

不论是 FDA 还是 Dr. Fauci 一直讲得很清楚啊：严格意义上应该遵循 phase III trial defined usage，同一种疫苗，打 protocol 定义的两针。

在缺乏疫苗供应的情况下，第1、第2针混打应该被视为是实验性、学术性质的。

混打被广泛承认，应该限于 完全接种了某种疫苗之后、对于加强针而言。

不要轻信政府的，考虑事情要自己思考。

混搭可以有效，但是安全未知，而且得不到药厂的支持，得不到美国的认可。公司更是没时间听你申诉。直接开除就完了。

而加拿大政府是没有热情和实力，替你出头的。

疫情两年了，如果这一点还学不会，那就真是没办法了。

 

[贵圈]

是的，加强针可以考虑混搭。

但是我依然不推荐。能不混搭就不要混搭。

 

[wei_cheng]

排除掉腺病毒载体重组疫苗 (它或许在别的领域还能东山再起，但在新冠疫苗方面就有局限性)， 完全接种了某种疫苗 (三期临床试验定义的两剂或三剂) 之后，对于加强针而言混打不同机理的疫苗是个并没有证实它有什么不好、理论上或许能调动不同免疫体系的方案，有待研究。

是的，加强针可以考虑混搭。

但是我依然不推荐。能不混搭就不要混搭。

 

[贵圈]

排除掉腺病毒载体重组疫苗 (它或许在别的领域还能东山再起，但在新冠疫苗方面就有局限性)， 完全接种了某种疫苗 (三期临床试验定义的两剂或三剂) 之后，对于加强针而言的混打不同机理的疫苗是个并没有证实它有什么不好、理论上或许能调动不同免疫体系的方案，有待研究。

有道理，但是，谁有资金和实力去做研究？

疫苗大厂

他们为什么要做混合实验？

他们如果不做混合尝试，那么别人是没有资金和能力完成这种双盲三期的。

 

[wei_cheng]

1. Vaccine-related adverse events surveillance 虽然无法做到随机临床试验，但的确也是有价值的研究，我认为两种不同机理的疫苗里如果没有类似腺病毒载体重组疫苗这样的系统性问题的话，一般并不会像药物相互作用那样造成 1+1>>2 的问题

2. 讲道理，将来有出现多联、多价疫苗的潜力，虽然并不等同于 两种不同机理的疫苗混打

有道理，但是，谁有资金和实力去做研究？

疫苗大厂

他们为什么要做混合实验？

他们如果不做混合尝试，那么别人是没有资金和能力完成这种双盲三期的。

 

[gocanoeing]

现在疫苗的防感染能力已经千疮百孔。还折腾强制。防疫意义不大。

你这不算宣扬疫苗无用论？

 

[贵圈]

Liangshabi

 

[贵圈]

1. 两个mRNA不要混搭，有条件的不要打什么AZ，圈儿哥都是第一时间善意提醒过大家的。

当初，我是谨慎研究过，决定不混搭。现在混搭的可怜了。

2. 一起反对疫苗强制措施吧。现在混搭的加拿大人失去了很多在国外的工作和自由。

当你是少数的时候，他们会毫不留情的欺负你。这个先例已经开了。而且在西方世界的绝望现状下，民粹的左派会迅速的推进对医疗少数群体的无充足理由的压迫。将自己的无能，转嫁给少数群体。对他们肆意剥夺。

3. 成人，没完成疫苗接种的现在赶紧。高潮要来了。

第三条

 

[贵圈]

看不懂人话的傻逼二百五

 

[贵圈]

因为混搭就可以失去工作。

这就是政府强制措施的真实面目。

现在疫苗的防感染能力已经千疮百孔。还折腾强制。防疫意义不大。官僚权力扩增倒是真的。

世界真的被疫情彻底改变了。无可奈何话谐趣。

看不懂人话的傻逼，二百五，狗日的，畜生不如的

我反对强制疫苗。但是强烈支持成人注射疫苗。怎么了。

玛丽隔壁，傻逼。毫无人性的东西。

就是你们这种狗日的太多。

 

[gocanoeing]

看不懂人话的傻逼，二百五，狗日的，畜生不如的

我反对强制疫苗。但是强烈支持成人注射疫苗。怎么了。

玛丽隔壁，傻逼。毫无人性的东西。

就是你们这种狗日的太多。

我有点想笑