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Antibacterials in Personal-Care Products Linked to Allergy Risk in Children
MEDIA CONTACT: Ekaterina Pesheva
EMAIL: epeshev1@jhmi.edu
PHONE: (410) 502-9433
June 18, 2012
Exposure to common antibacterial chemicals and preservatives found in soap, toothpaste, mouthwash and other personal-care products may make children more prone to a wide range of food and environmental allergies, according to new research from Johns Hopkins Children’s Center.
Results of the NIH-funded study are published online ahead of print June 18 in the Journal of Allergy and Clinical Immunology.
Using existing data from a national health survey of 860 children ages 6 to 18, Johns Hopkins researchers examined the relationship between a child’s urinary levels of antibacterials and preservatives found in many personal-hygiene products and the presence of IgE antibodies in the child’s blood. IgE antibodies are immune chemicals that rise in response to an allergen and are markedly elevated in people with allergies.
“We saw a link between level of exposure, measured by the amount of antimicrobial agents in the urine, and allergy risk, indicated by circulating antibodies to specific allergens,” said lead investigator Jessica Savage, M.D., M.H.S., an allergy and immunology fellow at Hopkins.
The researchers caution that the findings do not demonstrate that antibacterials and preservatives themselves cause the allergies, but instead suggest that these agents play a role in immune system development.
The investigators say their findings are also consistent with the so-called hygiene hypothesis, which has recently gained traction as one possible explanation behind the growing rates of food and environmental allergies in the developed world. The hypothesis suggests that early childhood exposure to common pathogens is essential in building healthy immune responses. Lack of such exposure, according to the theory, can lead to an overactive immune system that misfires against harmless substances such as food proteins, pollen or pet dander.
“The link between allergy risk and antimicrobial exposure suggests that these agents may disrupt the delicate balance between beneficial and bad bacteria in the body and lead to immune system dysregulation, which in turn raises the risk of allergies,” Savage added.
In the study, those with the highest urine levels of triclosan — an antibacterial agent used in soaps, mouthwash and toothpaste — had the highest levels of food IgE antibodies, and therefore the highest allergy risk, compared with children with the lowest triclosan levels. Children with the highest urinary levels of parabens — preservatives with antimicrobial properties used in cosmetics, food and medications — were more likely to have detectable levels of IgE antibodies to environmental allergens like pollen and pet dander, compared with those with low paraben levels.
The team initially zeroed in on seven ingredients previously shown to disrupt endocrine function in lab and animal studies. These compounds were bisphenol A — found in plastics — and triclosan, benzophenone-3 and propyl, methyl, butyl and ethyl parabens, found in personal-hygiene products and some foods and medications. Interestingly, triclosan and propyl and butyl parabens, all of which have antimicrobial properties, were the only ones associated with increased allergy risk in the current study, the researchers noted.
“This finding highlights the antimicrobial properties of these agents as a probable driving force behind their effect on the immune system,” said senior investigatorCorinne Keet, M.D., M.S., an allergist at Johns Hopkins Children’s Center.
Children with the highest urine levels of triclosan had nearly twice the risk of environmental allergies as children with the lowest urinary concentrations. Those with highest levels of propyl paraben in the urine had twice the risk of an environmental allergy. Food allergy risk was more than twice as pronounced in children with the highest levels of urinary triclosan as in children with the lowest triclosan levels. High paraben levels in the urine were not linked to food allergy risk.
To clarify the link between antimicrobial agents and allergy development, the researchers are planning a long-term study in babies exposed to antibacterial ingredients at birth, following them throughout childhood.
The research was funded by the National Institutes of Health training grant number T32AI007056-31.
Co-investigators on the research were Elizabeth Matsui, M.D., M.H.S., andRobert Wood, M.D., both of Hopkins.
Founded in 1912 as the children's hospital of the Johns Hopkins Medicine, the Johns Hopkins Children's Center offers one of the most comprehensive pediatric medical programs in the country, with more than 92,000 patient visits and nearly 9,000 admissions each year. Johns Hopkins Children Center is consistently ranked among the top children's hospitals in the nation by U.S. News & World Report. It is Maryland's largest children’s hospital and the only state-designated Trauma Service and Burn Unit for pediatric patients. It has recognized Centers of Excellence in dozens of pediatric subspecialties, including allergy, cardiology, cystic fibrosis, gastroenterology, nephrology, neurology, neurosurgery, oncology, pulmonary, and transplant. For more information, visit www.hopkinschildrens.org.
http://www.hopkinschildrens.org/Ant...ducts-Linked-to-Allergy-Risk-in-Children.aspx
Additive found in soap, toothpaste and shampoo is linked to cancer and liver disease
PUBLISHED: 20:01 GMT, 17 November 2014 | UPDATED: 20:23 GMT, 17 November 2014
An additive found in many liquid hand soaps and other common household products has been linked to cancer in a new study.
Triclosan is an antimicrobial commonly found in soaps, shampoos, toothpastes and many other household items.
Despite its widespread use, researchers have identified potentially serious consequences of long-term exposure to the chemical.
Triclosan is an antimicrobial found in many soaps, shampoos, toothpastes and many other household items
Their study, published by the journal Proceedings of the National Academy of Sciences, shows that triclosan causes liver fibrosis and cancer in lab mice.
Liver fibrosis is where persistent inflammation causes fibrous scar tissue to form around the liver cells and blood vessels.
Over time, it can cause cirrhosis which in turn can make the liver stop functioning.
However the researchers stress the findings are also relevant in humans, due to the processes they observed while conducting the study.
Triclosan is already under scrutiny by the Food and Drug Administration (FDA) in the United States due recent reports that it can disrupt hormones and impair muscle contraction.
Experts are concerned because triclosan is now so widely used in a variety of toiletries and household cosmetics.
Studies in the U.S. have found traces in 97 per cent of breast milk samples from lactating women and in the urine of nearly 75 per cent of people tested.
Triclosan is one of the seven most frequently detected compounds in streams across the United States.
While it seems common sense that antibacterial soap can protect against from illness caused by bacteria, this is not what the evidence shows.
More than four decades of research by the U.S. government’s Food And Drug Administration, along with numerous independent studies, have produced no evidence that triclosan, the active ingredient in many antibacterial soaps, hand gels and wipes, has any health benefits over old-fashioned soap and water.
One basic problem is that antibacterial soaps specifically target bacteria rather than viruses. But it is viruses that cause the majority of illnesses, such as colds and flu.
The most effective scientifically proven way to keep bacteria at bay is regular hand-washing with ordinary soap, along with good food hygiene in the kitchen.
Antibacterial soaps may actually cause health problems, too.
Evidence shows children with prolonged exposure to triclosan over months or years have a greater chance of developing allergies, including peanut allergies and hay fever, according to studies in the Journal of Allergy And Clinical Immunology in 2012, and in Environmental Health Perspectives in 2011.
This may be due to the fact that youngsters who use antibacterial soaps and cleansers reduce their exposure to bacteria.
Some research also suggests that the additives in antibacterial soaps could contribute to antibiotic resistance, a growing public health problem.
Author of the new study, Dr Robert Tukey, of the University of California, San Diego School of Medicine, said the chemical posed 'very real risks' to health.
'Triclosan's increasing detection in environmental samples and its increasingly broad use in consumer products may overcome its moderate benefit.
'[Instead, it may] present a very real risk of liver toxicity for people, as it does in mice, particularly when combined with other compounds with similar action.'
Dr Tukey and his colleagues found that triclosan compromised liver function in mice.
Those exposed to triclosan for six months - roughly equivalent to 18 human years - were more susceptible to chemical-induced liver tumours.
Their tumours were also larger and more frequent than in mice not exposed to triclosan.
Some research also suggests that the additives in antibacterial soaps could contribute to antibiotic resistance, a growing public health problem
The study suggests triclosan may do its damage by interfering with a protein responsible for detoxifying, or clearing away, foreign chemicals in the body.
To compensate for this stress, liver cells proliferate and turn fibrotic (hard and scarred) over time.
Repeated triclosan exposure and continued liver fibrosis eventually promote tumour formation.
Study co-leader Dr Bruce Hammock said: 'We could reduce most human and environmental exposures by eliminating uses of triclosan that are high volume, but of low benefit, such as inclusion in liquid hand soaps.
'Yet we could also for now retain uses shown to have health value, as in toothpaste, where the amount used is small.'
In May, a study directly linked common household chemicals with damage to human sperm for the first time.
The scientists said that the ‘ubiquitous’ chemicals in everyday products may be contributing to widespread fertility problems in the Western world.
The German and Danish researchers tested almost 100 everyday chemicals – and discovered that a third affected sperm.
MEDIA CONTACT: Ekaterina Pesheva
EMAIL: epeshev1@jhmi.edu
PHONE: (410) 502-9433
June 18, 2012
Exposure to common antibacterial chemicals and preservatives found in soap, toothpaste, mouthwash and other personal-care products may make children more prone to a wide range of food and environmental allergies, according to new research from Johns Hopkins Children’s Center.
Results of the NIH-funded study are published online ahead of print June 18 in the Journal of Allergy and Clinical Immunology.
Using existing data from a national health survey of 860 children ages 6 to 18, Johns Hopkins researchers examined the relationship between a child’s urinary levels of antibacterials and preservatives found in many personal-hygiene products and the presence of IgE antibodies in the child’s blood. IgE antibodies are immune chemicals that rise in response to an allergen and are markedly elevated in people with allergies.
“We saw a link between level of exposure, measured by the amount of antimicrobial agents in the urine, and allergy risk, indicated by circulating antibodies to specific allergens,” said lead investigator Jessica Savage, M.D., M.H.S., an allergy and immunology fellow at Hopkins.
The researchers caution that the findings do not demonstrate that antibacterials and preservatives themselves cause the allergies, but instead suggest that these agents play a role in immune system development.
The investigators say their findings are also consistent with the so-called hygiene hypothesis, which has recently gained traction as one possible explanation behind the growing rates of food and environmental allergies in the developed world. The hypothesis suggests that early childhood exposure to common pathogens is essential in building healthy immune responses. Lack of such exposure, according to the theory, can lead to an overactive immune system that misfires against harmless substances such as food proteins, pollen or pet dander.
“The link between allergy risk and antimicrobial exposure suggests that these agents may disrupt the delicate balance between beneficial and bad bacteria in the body and lead to immune system dysregulation, which in turn raises the risk of allergies,” Savage added.
In the study, those with the highest urine levels of triclosan — an antibacterial agent used in soaps, mouthwash and toothpaste — had the highest levels of food IgE antibodies, and therefore the highest allergy risk, compared with children with the lowest triclosan levels. Children with the highest urinary levels of parabens — preservatives with antimicrobial properties used in cosmetics, food and medications — were more likely to have detectable levels of IgE antibodies to environmental allergens like pollen and pet dander, compared with those with low paraben levels.
The team initially zeroed in on seven ingredients previously shown to disrupt endocrine function in lab and animal studies. These compounds were bisphenol A — found in plastics — and triclosan, benzophenone-3 and propyl, methyl, butyl and ethyl parabens, found in personal-hygiene products and some foods and medications. Interestingly, triclosan and propyl and butyl parabens, all of which have antimicrobial properties, were the only ones associated with increased allergy risk in the current study, the researchers noted.
“This finding highlights the antimicrobial properties of these agents as a probable driving force behind their effect on the immune system,” said senior investigatorCorinne Keet, M.D., M.S., an allergist at Johns Hopkins Children’s Center.
Children with the highest urine levels of triclosan had nearly twice the risk of environmental allergies as children with the lowest urinary concentrations. Those with highest levels of propyl paraben in the urine had twice the risk of an environmental allergy. Food allergy risk was more than twice as pronounced in children with the highest levels of urinary triclosan as in children with the lowest triclosan levels. High paraben levels in the urine were not linked to food allergy risk.
To clarify the link between antimicrobial agents and allergy development, the researchers are planning a long-term study in babies exposed to antibacterial ingredients at birth, following them throughout childhood.
The research was funded by the National Institutes of Health training grant number T32AI007056-31.
Co-investigators on the research were Elizabeth Matsui, M.D., M.H.S., andRobert Wood, M.D., both of Hopkins.
Founded in 1912 as the children's hospital of the Johns Hopkins Medicine, the Johns Hopkins Children's Center offers one of the most comprehensive pediatric medical programs in the country, with more than 92,000 patient visits and nearly 9,000 admissions each year. Johns Hopkins Children Center is consistently ranked among the top children's hospitals in the nation by U.S. News & World Report. It is Maryland's largest children’s hospital and the only state-designated Trauma Service and Burn Unit for pediatric patients. It has recognized Centers of Excellence in dozens of pediatric subspecialties, including allergy, cardiology, cystic fibrosis, gastroenterology, nephrology, neurology, neurosurgery, oncology, pulmonary, and transplant. For more information, visit www.hopkinschildrens.org.
http://www.hopkinschildrens.org/Ant...ducts-Linked-to-Allergy-Risk-in-Children.aspx
Additive found in soap, toothpaste and shampoo is linked to cancer and liver disease
- The antimicrobial triclosan is found in hundreds of household products
- Has been linked with health problems and antibiotic resistance
- New study suggests it is linked with liver disease and cancer
PUBLISHED: 20:01 GMT, 17 November 2014 | UPDATED: 20:23 GMT, 17 November 2014
An additive found in many liquid hand soaps and other common household products has been linked to cancer in a new study.
Triclosan is an antimicrobial commonly found in soaps, shampoos, toothpastes and many other household items.
Despite its widespread use, researchers have identified potentially serious consequences of long-term exposure to the chemical.
Triclosan is an antimicrobial found in many soaps, shampoos, toothpastes and many other household items
Their study, published by the journal Proceedings of the National Academy of Sciences, shows that triclosan causes liver fibrosis and cancer in lab mice.
Liver fibrosis is where persistent inflammation causes fibrous scar tissue to form around the liver cells and blood vessels.
Over time, it can cause cirrhosis which in turn can make the liver stop functioning.
However the researchers stress the findings are also relevant in humans, due to the processes they observed while conducting the study.
Triclosan is already under scrutiny by the Food and Drug Administration (FDA) in the United States due recent reports that it can disrupt hormones and impair muscle contraction.
Experts are concerned because triclosan is now so widely used in a variety of toiletries and household cosmetics.
Studies in the U.S. have found traces in 97 per cent of breast milk samples from lactating women and in the urine of nearly 75 per cent of people tested.
Triclosan is one of the seven most frequently detected compounds in streams across the United States.
While it seems common sense that antibacterial soap can protect against from illness caused by bacteria, this is not what the evidence shows.
More than four decades of research by the U.S. government’s Food And Drug Administration, along with numerous independent studies, have produced no evidence that triclosan, the active ingredient in many antibacterial soaps, hand gels and wipes, has any health benefits over old-fashioned soap and water.
One basic problem is that antibacterial soaps specifically target bacteria rather than viruses. But it is viruses that cause the majority of illnesses, such as colds and flu.
The most effective scientifically proven way to keep bacteria at bay is regular hand-washing with ordinary soap, along with good food hygiene in the kitchen.
Antibacterial soaps may actually cause health problems, too.
Evidence shows children with prolonged exposure to triclosan over months or years have a greater chance of developing allergies, including peanut allergies and hay fever, according to studies in the Journal of Allergy And Clinical Immunology in 2012, and in Environmental Health Perspectives in 2011.
This may be due to the fact that youngsters who use antibacterial soaps and cleansers reduce their exposure to bacteria.
Some research also suggests that the additives in antibacterial soaps could contribute to antibiotic resistance, a growing public health problem.
Author of the new study, Dr Robert Tukey, of the University of California, San Diego School of Medicine, said the chemical posed 'very real risks' to health.
'Triclosan's increasing detection in environmental samples and its increasingly broad use in consumer products may overcome its moderate benefit.
'[Instead, it may] present a very real risk of liver toxicity for people, as it does in mice, particularly when combined with other compounds with similar action.'
Dr Tukey and his colleagues found that triclosan compromised liver function in mice.
Those exposed to triclosan for six months - roughly equivalent to 18 human years - were more susceptible to chemical-induced liver tumours.
Their tumours were also larger and more frequent than in mice not exposed to triclosan.
Some research also suggests that the additives in antibacterial soaps could contribute to antibiotic resistance, a growing public health problem
The study suggests triclosan may do its damage by interfering with a protein responsible for detoxifying, or clearing away, foreign chemicals in the body.
To compensate for this stress, liver cells proliferate and turn fibrotic (hard and scarred) over time.
Repeated triclosan exposure and continued liver fibrosis eventually promote tumour formation.
Study co-leader Dr Bruce Hammock said: 'We could reduce most human and environmental exposures by eliminating uses of triclosan that are high volume, but of low benefit, such as inclusion in liquid hand soaps.
'Yet we could also for now retain uses shown to have health value, as in toothpaste, where the amount used is small.'
In May, a study directly linked common household chemicals with damage to human sperm for the first time.
The scientists said that the ‘ubiquitous’ chemicals in everyday products may be contributing to widespread fertility problems in the Western world.
The German and Danish researchers tested almost 100 everyday chemicals – and discovered that a third affected sperm.
