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伊维菌素
WHO 指南指出不建议在临床环境中用于 COVID-19 患者。
https://bbs.comefromchina.com/javascript:;
Alexandra Mae Jones
CTVNews.ca writer
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Published Nov. 10, 2023 5:21 a.m. EST
Because VV116 was created to tackle COVID-19 specifically, research assessing its effectiveness is still new.
It is an oral antiviral drug which induces RNA chain termination to interfere with the spread of the virus. While WHO notes that it “does not seem to be associated with increased adverse effects,” there still isn’t enough data to recommend it at this stage, according to the agency.
Only one randomised control trial has formally assessed its effectiveness by comparing it with Paxlovid. Although the trial found that VV116 was noninferior compared to Paxlovid, no deaths were recorded in the entire trial, making it difficult to assess if the medication itself had any impact in preventing mortality, WHO stated. There was also no placebo control group in the trial.
The updated guidelines reflect that WHO strongly recommends against VV116 being used for COVID-19 patients regardless of how serious their illness is, except in the context of a clinical trial.
But WHO is now also strongly warning against its use for those with non-severe COVID-19, even in research settings.
New research that has emerged since 2021 has reduced the uncertainty surrounding whether or not it is worth continuing randomised controlled trials assessing ivermectin’s usage for those with non-severe COVID-19, WHO states.
This data shows a “very low likelihood of benefit,” both due to research that has tested and also due to the “lack of biological basis for any effect of ivermectin on the virus.” Essentially, it was always scientifically unlikely that it would have an effect, and it hasn’t been shown to have one.
Ivermectin is conditionally recommended against in research settings for severe cases of COVID-19 as well.
“Use of ivermectin risks diverting attention and resources away from care likely to provide a benefit such as nirmatrelvir/ritonavir, remdesivir, and molnupiravir as well as supportive care interventions,” WHO states, adding that it risks causing drug shortages for those suffering from issues ivermectin is actually designed to tackle.
Drugs such as hydroxychloroquine, lopinavir-ritonavir, casirivimab and imdevimab are strongly recommended to not be used with any COVID-19 patients, according to WHO.
RELATED IMAGES
In this Thursday Oct. 15, 2020 file photo, a bottle containing the drug Remdesivir is held by a health worker at the Institute of Infectology of Kenezy Gyula Teaching Hospital of the University of Debrecen in Debrecen, Hungary. (Zsolt Czegledi/MTI via AP, File)
WHO 指南指出不建议在临床环境中用于 COVID-19 患者。
WHO 表示,强烈建议任何 COVID-19 患者不要使用羟氯喹、洛匹那韦-利托那韦、卡西里单抗和依德维单抗等药物。
Ivermectin warnings, a new COVID-19 antiviral, a changing threshold for care: These are the WHO's updated treatment guidelines
https://bbs.comefromchina.com/javascript:;
Alexandra Mae Jones
CTVNews.ca writer
Follow | Contact
Published Nov. 10, 2023 5:21 a.m. EST
In this Sept. 10, 2021, file photo, a syringe of ivermectin, a drug used to kill worms and other parasites, rests on the box it was packaged in, in Olympia, Wash. (AP Photo/Ted S. Warren, File)
UPDATED WARNINGS FOR USE OF IVERMECTIN AND A NEW ANTIVIRAL
VV116
When COVID-19 emerged in late 2019 and quickly spread across the globe in 2020, researchers immediately began to investigate which existing drugs could be repurposed to treat the virus. But researchers in China also began to develop a therapeutic aimed specifically at tackling COVID-19, which they presented preliminary research for in 2021.Because VV116 was created to tackle COVID-19 specifically, research assessing its effectiveness is still new.
It is an oral antiviral drug which induces RNA chain termination to interfere with the spread of the virus. While WHO notes that it “does not seem to be associated with increased adverse effects,” there still isn’t enough data to recommend it at this stage, according to the agency.
Only one randomised control trial has formally assessed its effectiveness by comparing it with Paxlovid. Although the trial found that VV116 was noninferior compared to Paxlovid, no deaths were recorded in the entire trial, making it difficult to assess if the medication itself had any impact in preventing mortality, WHO stated. There was also no placebo control group in the trial.
The updated guidelines reflect that WHO strongly recommends against VV116 being used for COVID-19 patients regardless of how serious their illness is, except in the context of a clinical trial.
Ivermectin
Despite widespread use of ivermectin, a medication approved for use in humans to treat parasitic infections such as river blindness, it is still not recommended for use with COVID-19 patients in clinical settings, the WHO guidelines state.But WHO is now also strongly warning against its use for those with non-severe COVID-19, even in research settings.
New research that has emerged since 2021 has reduced the uncertainty surrounding whether or not it is worth continuing randomised controlled trials assessing ivermectin’s usage for those with non-severe COVID-19, WHO states.
This data shows a “very low likelihood of benefit,” both due to research that has tested and also due to the “lack of biological basis for any effect of ivermectin on the virus.” Essentially, it was always scientifically unlikely that it would have an effect, and it hasn’t been shown to have one.
Ivermectin is conditionally recommended against in research settings for severe cases of COVID-19 as well.
“Use of ivermectin risks diverting attention and resources away from care likely to provide a benefit such as nirmatrelvir/ritonavir, remdesivir, and molnupiravir as well as supportive care interventions,” WHO states, adding that it risks causing drug shortages for those suffering from issues ivermectin is actually designed to tackle.
Drugs such as hydroxychloroquine, lopinavir-ritonavir, casirivimab and imdevimab are strongly recommended to not be used with any COVID-19 patients, according to WHO.
RELATED IMAGES
In this Thursday Oct. 15, 2020 file photo, a bottle containing the drug Remdesivir is held by a health worker at the Institute of Infectology of Kenezy Gyula Teaching Hospital of the University of Debrecen in Debrecen, Hungary. (Zsolt Czegledi/MTI via AP, File)
Ivermectin warnings, a new COVID-19 antiviral, a changing threshold for care: These are the WHO's updated treatment guidelines
The World Health Organization has updated its guidelines for the treatment of COVID-19 patients, including categories of hospitalization risk to help doctors tailor treatment, and recommendations surrounding a new antiviral designed specifically to tackle the disease.
www.ctvnews.ca